Publications by authors named "Jaya Kanduri"
Sex Disparities in the Management, Outcomes, and Transfer of Patients Hospitalized for Cardiogenic Shock.
J Soc Cardiovasc Angiogr Interv
March 2024
Article Synopsis
- Previous studies indicated that women experience worse outcomes than men when suffering from cardiogenic shock (CS), especially when treated at less advanced hospitals (spokes) compared to specialized centers (hubs).
- An analysis of over 618,000 hospitalizations revealed that women were less likely to be transferred to hubs, underwent fewer invasive procedures, and had higher in-hospital mortality rates compared to men.
- Findings suggest a need for further research to address the sex disparities in treatment and outcomes for women with cardiogenic shock, as they face greater challenges in receiving optimal care.
Article Synopsis
- - This review focuses on congenital coronary artery fistulas (CAFs) in adults, detailing their presentation, diagnosis, and management.
- - CAFs are classified into two types: coronary-cameral and coronary arteriovenous, with risks like thrombosis and myocardial infarction increasing for larger or symptomatic ones.
- - Management options for CAFs include closure through transcatheter techniques or surgery, ongoing medical therapy, and lifelong monitoring due to their complex nature.
Background: Although much attention has been paid to admission and transfer patterns for cardiogenic shock, contemporary data are lacking on decompensated heart failure (HF) admissions and transfers and the impact of advanced therapy centers (ATCs) on outcomes.
Methods: HF hospitalizations were obtained from the Nationwide Readmissions Database 2016 to 2019. Centers performing at least 1 heart transplant or left ventricular assist device were classified as ATCs.
Background: Coronary artery fistulae are abnormal communications of coronary arteries with systemic vasculature, pulmonary vasculature, or cardiac chambers. Use of multimodality imaging can be paramount to understanding anatomical and functional features of these complex vascular lesions, therefore optimizing success of potential curative interventions.
Case Summary: We present two patients with incidentally discovered giant aneurysmal coronary arteries with distal fistulous connections to the coronary sinus, which were successfully closed percutaneously with Amplatzer Septal Occluders using the assistance of three-dimensional (3D) printed heart models.
Article Synopsis
- The study examined the effects of pulmonary embolism response teams (PERTs) on patient outcomes by comparing data from three years before and after their implementation at a specific hospital.
- It found that despite an increase in risk assessment methods post-PERT, there was no significant difference in pulmonary embolism-related mortality rates (2.6% pre-PERT vs 2.9% post-PERT).
- Also, while the overall use of advanced therapies remained the same, the utilization patterns changed, with a decrease in systemic thrombolysis and an increase in catheter-directed therapy after PERT implementation.
Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise for CAD patients is unclear. Coronary artery calcification (CAC) is associated with increased cardiovascular disease (CVD) events and mortality.
View Article and Find Full Text PDFBackground: The fluoropyrimidines, 5-fluorouracil (5-FU) and capecitabine, are commonly used chemotherapeutic agents that have been associated with coronary vasospasm.
Methods: In this retrospective case-control study, we identified patients at our institution who received 5-FU or capecitabine in 2018. We compared characteristics of patients who experienced cardiotoxicity with controls.
Article Synopsis
- Fluoropyrimidines are chemotherapy drugs effective against solid tumors, but their use can lead to serious heart-related side effects, known as cardiotoxicity.
- Symptoms of this cardiotoxicity can vary widely, including chest pain, heart attacks, and even sudden cardiac death.
- There are several proposed causes for these heart issues, such as blood vessel spasms and direct damage to heart tissue, and more research is needed to find effective preventive measures.
Immune-mediated necrotizing myopathy is a very rare inflammatory disease affecting skeletal muscles. Immune-mediated necrotizing myopathy may be associated with myositis-specific autoantibodies including anti-single recognition particle and anti-3-hydroxy-3- methylglutaryl-coenzyme A reductase, infectious agents (HIV or hepatitis C), other connective tissue disorders (such as scleroderma), and malignancy. We reported a 28-year-old healthy woman presented with subacute onset ascending muscle weakness 2 weeks after an annual influenza vaccination.
View Article and Find Full Text PDFHealth Care Student Knowledge and Willingness to Work in Infectious Disease Outbreaks.
Disaster Med Public Health Prep
December 2017
Objective: Health care workers are critical first responders. Understanding which factors motivate their willingness to work (WTW) during infectious disease outbreaks may guide improvements in preparedness. The perspective of health care students, the future workforce, remains largely unexplored.
View Article and Find Full Text PDFCarotid Stenosis in Cardiac Surgery-No Difference in Postoperative Outcomes.
Thorac Cardiovasc Surg
April 2018
Article Synopsis
- - The study investigates outcomes of cardiac surgery in 1,357 patients with asymptomatic carotid stenosis, finding that 29.7% had this condition, mostly presenting as moderate stenosis.
- - Most patients with stenosis were older and more likely to be female, but overall rates of postoperative complications and mortality were similar to those without stenosis.
- - The research concludes that asymptomatic carotid stenosis does not increase the risk of complications or death after cardiac surgery, suggesting that preemptive carotid revascularization may not be necessary.
Article Synopsis
- Osteosarcomas are the most common bone cancers in kids and teens, and researchers developed a retroviral gene delivery system to target these tumors in mice using a modified feline leukemia virus envelope.
- The system uses a vector that expresses the luciferase gene, allowing for real-time tracking of gene delivery and expression within the tumors.
- Results indicate that this novel approach effectively delivers and expresses genes in live mice, showcasing its potential for further research and treatment developments.