Macrophage Targeted Cellular Carriers for Effective Delivery of Anti-Tubercular Drugs.

Background: Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB). Multi-drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised.

Methods: One third of the world's population is infected with TB.

Nanoemulsion-Based Transdermal Drug Delivery System for the Treatment of Tuberculosis.

Background: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the drugs solubility, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is admirable and offered several advantages over others drug delivery.

Methods: For nanoemulsions formulation, they have to deliver the energetic element at the specific organ with nominal uneasiness.

Development and evaluation of anti-malarial bio-conjugates: artesunate-loaded nanoerythrosomes.

Biodegradable cellular carrier has desired properties for achieving effective long-term controlled release of drugs having short half life. To reduce the undesired effects of drug, advanced drug delivery systems are needed which are based on specific cell targeting module. Artesunate (ART) conjugation on nanoerythrosomes (NE) can have controlled delivery to avoid drug leakage, increase the stability, and reduce cost and toxicities.

Biodegradable long circulating cellular carrier for antimalarial drug pyrimethamine.

Objective: The objective of the present study was to develop targeted engineered nanoerythrosomes based intravenous formulation of antimalarial drug pyrimethamine.

Material And Methods: The nanoerythrosomes formulation was developed by sonication method and optimized for effective drug loading at variable drug concentration, surface morphology, viscosity and sedimentation volume.

Results: The in vitro drug release of formulated product was found to be delayed after 8 hours, having good stability at 4 ± 1°C and showing controlled in vivo release.

Periodontal Status amongst Substance Abusers in Indian Population.

Background. In India there have been limited number of studies on periodontal status among drug addicts, and thus this study aims to assess the Oral hygiene and periodontal status in substance abusers and compare it with non-substance abusers. Methods.