Publications by authors named "Jay Z Yin"
Article Synopsis
- KEOPS is a crucial enzyme complex that modifies tRNAs, specifically adding a N-threonylcarbamoyl adenosine (tA) modification essential for protein synthesis in eukaryotes and archaea.
- Mutations in any of the KEOPS subunits can cause Galloway Mowat Syndrome (GAMOS) in humans, highlighting the complex's significance in cellular function.
- Recent cryogenic electron microscopy studies revealed how KEOPS interacts with tRNA, showing that its structure changes during modification and emphasizing the roles of all subunits, especially Bud32, in regulating tRNA modification.
Article Synopsis
- GCN2 is a kinase that inhibits protein synthesis by phosphorylating eIF2α when it detects uncharged tRNA and stalled ribosomes during stress.
- Researchers explored the structure of GCN2's HisRS-like domain using cryo-electron microscopy (cryoEM), revealing it is adapted for tRNA binding rather than histidine or ATP binding.
- Studies indicate that GCN2's HisRS-like domain functions as a pseudoenzyme, providing new insights into its regulatory mechanisms and overall function.
