Publications by authors named "Jay Y Chhabra"
Article Synopsis
- Stem cells transition from a "stemness" state to differentiated states through coordinated gene regulation mechanisms, but understanding how these processes are intricately balanced is complex due to overlapping translational controls.
- The study focuses on fruit flies' neural stem cells, demonstrating that the transcription factor Fru is critical for controlling the expression of stemness genes, particularly by regulating a repressive histone mark (H3K27me3) in key gene regions.
- The findings suggest that maintaining low levels of H3K27me3 is essential for fine-tuning gene expression in stem cells, a mechanism that may be similar in various organisms, including humans.
