A bird's-eye view of research practices in mathematical cognition, learning, and instruction: Reimagining the status quo.

Research on mathematical cognition, learning, and instruction (MCLI) often takes cognition as its point of departure and considers instruction at a later point in the research cycle. In this article, we call for psychologists who study MCLI to reflect on the "status quo" of their research practices and to consider making instruction an earlier and more central aspect of their work. We encourage scholars of MCLI (a) to consider the needs of educators and schools when selecting research questions and developing interventions; (b) to compose research teams that are diverse in the personal, disciplinary, and occupational backgrounds of team members; (c) to make efforts to broaden participation in research and to conduct research in authentic settings; and (d) to communicate research in ways that are accessible to practitioners and to the general public.

On a historical note: the legacy of Thomas Hodgkin.

Physicians in the practice of insurance medicine are exposed to an unbelievable spectrum of pathology. This series of short biographies is intended to give the reader a quick overview of the history of diseases encountered in our everyday practice and to see "the face behind the name." In the first article of this series, I wish to pay homage to one of the "great men of Guy's," Dr.

Images in pathology: Alzheimer's disease.

The review describes the histopathology and pathophysiology of Alzheimer's disease.

Ocular motility changes after subtenon carboplatin chemotherapy for retinoblastoma.

Background: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma.

Objective: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.

Methods: We noted abnormal ocular motility in 10 consecutive patients with retinoblastoma who had received subtenon carboplatin.

Characteristics of prolonged afterdischarges in children with malformations of cortical development.

We investigated aberrant cortical excitability in malformations of cortical development From subdural electrodes, we recorded afterdischarges lasting > or = 6 seconds in 12 of 13 patients with malformations of cortical development and 6 of 10 pediatric patients with nonmalformations of cortical development and reviewed amperage thresholds, distribution of afterdischarges, and motor responses. In patients with malformation of cortical development, motor response thresholds were high; afterdischarge and motor response thresholds, which essentially overlapped, inversely correlated with age (P < .01); afterdischarge thresholds declined with age; and 8 patients showed afterdischarges in remote sites.

Basilar artery duplication associated with pituitary duplication: a new finding.

Pituitary duplication is a rare malformation, reported previously in approximately 18 patients. It is usually unsuspected before imaging, although it occurs most commonly in association with complicated midline and skull base anomalies. It is easily shown by MR imaging.

Centronuclear myopathy and cardiomyopathy requiring heart transplant.

Centronuclear myopathy has been extremely rarely associated with cardiomyopathy, which can lead to heart failure and premature death. We report the case of a 3.5-year-old girl with early-onset dilated cardiomyopathy, biventricular hypertrophy and histologic features suggestive of centronuclear myopathy.

Microwindow selection for high-spectral-resolution sounders.

The recent development of satellite instruments that obtain spectrally resolved measurements of the atmosphere has highlighted the problem of how to determine the best subsets, or microwindows, of such spectra for retrievals of temperature and composition. A technique is described that maximizes the information content (or some other figure of merit) based on the modeling of the propagation of systematic as well as random error terms through the retrieval process. Apart from selecting microwindows, this technique can also prioritize existing microwindows for different circumstances and provides a full error analysis of the retrieval.

MEG predicts epileptic zone in lesional extrahippocampal epilepsy: 12 pediatric surgery cases.

Purpose: To discover whether the spatial distribution of spike sources determined by magnetoencephalography (MEG) provides reliable information for planning surgery and predicting outcomes in pediatric patients with lesional extrahippocampal epilepsy.

Methods: We retrospectively studied 12 children with extrahippocampal epilepsy secondary to cortical dysplasia (CD), tumor, or porencephalic cyst. We compared interictal MEG spike source locations and somatosensory evoked fields derived from equivalent-current dipole modeling with intraoperative or extraoperative electrocorticography (ECoG).

Clinicopathological correlation of congenital corneal opacification using ultrasound biomicroscopy.

Aim: To investigate the correlation between clinical, high frequency ultrasound biomicroscopy (UBM) and, where possible, histological findings in cases of congenital corneal opacification presenting to the departments of ophthalmology, Great Ormond Street Hospital for Children, London, and the Hospital for Sick Children, Toronto, Canada.

Method: 22 eyes of 13 children (age range 3-225 days) with congenitally opaque corneas were examined. UBM was performed using the ultrasound biomicroscope (Allergan-Humphrey).

Disorders of cortical formation: radiologic-pathologic correlation.

The advent of newer imaging techniques, such as high-resolution MR imaging and surface reconstructions of three-dimensional data sets, has led to a greater in vivo understanding of cortical malformations of the brain. Disorders of cortical formation are illustrated with routine imaging, surface reconstruction, and pathogenic specimens.

Radiologic-pathologic correlation in focal cortical dysplasia and hemimegalencephaly in 18 children.

To describe the radiologic-pathologic correlation in children who underwent epilepsy surgery for medically intractable epilepsy with pathologically confirmed focal cortical dysplasia and hemimegalencephaly, we conducted a retrospective review on the magnetic resonance imaging and pathology of 18 children (10 boys and 8 girls). The preoperative MRIs were reviewed by one neuroradiologist who did not know the radiologic diagnosis and the pathology reports. MRI revealed focal cortical dysplasia (10), hemimegalencephaly (3), hamartomas (2), polymicrogyria (1), pial hemosiderosis (1), and no abnormality (1).

Malignant rolandic-sylvian epilepsy in children: diagnosis, treatment, and outcomes.

Objective: To describe the diagnosis, treatment, and outcomes in children with malignant rolandic-sylvian epilepsy (MRSE), defined as a form of epilepsy characterized by sensorimotor seizures, medical refractoriness, normal MRI, frontocentrotemporal EEG spikes, rolandic-sylvian spike sources on magnetoencephalography (MEG), and cognitive problems.

Methods: A retrospective chart analysis of seven patients who had shown these characteristics and undergone extensive diagnostic testing, including MEG and intracranial video-EEG was performed.

Results: Interictal scalp EEG spikes were seen over the frontocentrotemporal regions bilaterally (6) and unilaterally (1).