Time-series analyses of air pollution and mortality in the United States: a subsampling approach.

Background: Hierarchical Bayesian methods have been used in previous papers to estimate national mean effects of air pollutants on daily deaths in time-series analyses.

Objectives: We obtained maximum likelihood estimates of the common national effects of the criteria pollutants on mortality based on time-series data from ≤ 108 metropolitan areas in the United States.

Methods: We used a subsampling bootstrap procedure to obtain the maximum likelihood estimates and confidence bounds for common national effects of the criteria pollutants, as measured by the percentage increase in daily mortality associated with a unit increase in daily 24-hr mean pollutant concentration on the previous day, while controlling for weather and temporal trends.

Potency factors for risk assessment at Libby, Montana.

We reanalyzed the Libby vermiculite miners' cohort assembled by Sullivan to estimate potency factors for lung cancer, mesothelioma, nonmalignant respiratory disease (NMRD), and all-cause mortality associated with exposure to Libby fibers. Our principal statistical tool for analyses of lung cancer, NMRD, and total mortality in the cohort was the time-dependent proportional hazards model. For mesothelioma, we used an extension of the Peto formula.

Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973-2005.

We analyzed mesothelioma incidence in the Surveillance, Epidemiology, and End Results (SEER) database over the period 1973-2005 using extensions of the age-period-cohort (APC) models. In these analyses, the usual non-specific age effects of the conventional APC models were replaced by hazard functions derived from two multistage models of carcinogenesis, the Armitage-Doll model and the two-stage clonal expansion (TSCE) model. The extended APC models described the incidence data on pleural and peritoneal mesotheliomas well.

Combining perfluoroalkane acid exposure levels for risk assessment.

Perfluoroalkane acids are present in biologic samples from >90% of people in the developed world. Because people may be exposed to multiple perfluoroalkane acids, it is reasonable to consider whether the exposure levels of these agents can be combined for risk assessment purposes. To investigate this possibility, we considered whether the literature on perfluoroalkane acids could be used to justify a scaling system analogous to the Toxic Equivalency Factor (TEF) system used for polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans.

Categorization and nomenclature of vitreous silicate wools.

There is substantial interest among government agencies in categorizing fibers for hazard classification purposes, particularly the commercially important synthetic vitreous fibers (e.g., rock wool, slag wool, glass wool, and refractory ceramic fibers).