Publications by authors named "Jay Padalia"
Understanding how the protozoan protein degradation pathway is regulated could uncover new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used the severe diarrhea-causing Entamoeba histolytica to study its function in medically significant protozoa. We show that CSN is an essential upstream regulator of parasite protein degradation.
View Article and Find Full Text PDFTargeting virulence factors represents a promising alternative approach to antimicrobial therapy, through the inhibition of pathogenic pathways that result in host tissue damage. Yet, virulence inhibition remains an understudied area in parasitology. Several medically important protozoan parasites such as Plasmodium, Entamoeba, Toxoplasma, and Leishmania secrete an inflammatory macrophage migration inhibitory factor (MIF) cytokine homolog, a virulence factor linked to severe disease.
View Article and Find Full Text PDFTissue Destruction Caused by Parasite Cell Death, Inflammation, Invasion, and the Gut Microbiome.
Curr Clin Microbiol Rep
January 2019
Article Synopsis
- A protozoan parasite causes amebiasis, which results in significant health issues globally due to tissue destruction.
- Recent research has uncovered new mechanisms of tissue damage, such as trogocytosis, a parasite cytokine that fuels inflammation, and the parasitic manipulation of the host's immune response.
- Future research should aim at targeting these mechanisms to create better prevention and treatment strategies for amebiasis.