Publications by authors named "Jay Hung"
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of corticosteroids in treating pediatric sepsis and septic shock by reviewing multiple databases and clinical trials up to September 2023.
- A total of 16 randomized controlled trials involving 973 patients were analyzed, indicating that corticosteroid treatment might lower mortality rates, reduce hospital stays, and decrease time spent in pediatric intensive care.
- Although corticosteroids were linked to a risk of gastrointestinal bleeding, they did not show a higher risk of secondary infections, and the quality of the evidence was rated as low to very low.
Introduction: This systematic review aimed to assess the efficacy and safety of hydrocortisone, ascorbic acid, and thiamine (HAT) combination therapy in patients with sepsis and septic shock.
Methods: We conducted a database search in MEDLINE, Embase, CENTRAL, Web of Science, and CNKI for randomised controlled trials (RCTs) comparing HAT against placebo/standard of care or against hydrocortisone in sepsis/septic shock patients. Outcomes included mortality, ICU/hospital length of stay (LOS), vasopressor durations, mechanical ventilation durations, change in SOFA at 72 h, and adverse events.