Publications by authors named "Jay H Park"

Food allergies affect millions of individuals worldwide, significantly impacting personal health and the economy. While avoiding allergenic foods remains the primary management strategy, consumers lack reliable means for immediate allergen detection in everyday dining settings. Here, we present iEAT2 (integrated Exogenous Allergen Test 2), an advanced electrochemical sensing system for rapid, on-site food allergen detection.

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As the demand for clean water intensifies, developing effective methods for removing pollutants from contaminated sources becomes increasingly crucial. This work establishes a method for additive manufacturing of functional polymer sorbents with hollow porous features, designed to enhance interactions with organic micropollutants. Specifically, core-shell filaments are used as the starting materials, which contain polypropylene (PP) as the shell and poly(acrylonitrile-co-butadiene-co-styrene) as the core, to fabricate 3-dimensional (3D) structures on-demand via material extrusion.

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Article Synopsis
  • Dedifferentiated liposarcoma of the extremities (DDL-E) is a rare condition, and this study analyzed its clinical features and surgical resection margins from 107 patients across 5 sarcoma centers between 2004 and 2023.
  • The 5-year survival rates showed promising outcomes, with local recurrence free survival at 84.7% and disease-specific survival at 87.8%, although larger tumor size was linked to a higher risk of metastasis.
  • The research indicates that while localized DDL-E typically has a good prognosis, there is a need for more research on the optimal surgical approach, particularly concerning resection margins at the well-differentiated component of the tumor.
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This study aimed to upcycle a byproduct of the edible oil industry, cold-pressed nettle seed meal (CPNSM), into a plant-based emulsifier, thereby increasing the sustainability of the food system. The protein content of the nettle seed protein (NSP) powder was 48.3% with glutamic acid (16.

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Aims: This study aimed to compare the performance of survival prediction models for bone metastases of the extremities (BM-E) with pathological fractures in an Asian cohort, and investigate patient characteristics associated with survival.

Methods: This retrospective cohort study included 469 patients, who underwent surgery for BM-E between January 2009 and March 2022 at a tertiary hospital in South Korea. Postoperative survival was calculated using the PATHFx3.

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The substitution of meat products in the human diet with plant-based analogs is growing due to environmental, ethical, and health reasons. In this study, the potential of fiber-spinning technology was explored to spin protein fiber mimicking the structural element of meat muscle for the purpose of developing plant-based meat analogs. Overall, this approach involved extruding fine fibers and then assembling them into hierarchical fibrous structures resembling those found in whole muscle meat products.

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Thermoplastic parts manufactured via fused filament fabrication (FFF) have limited strength and toughness compared to other types of polymer additive and subtractive manufacturing. Low strength results from poor interlayer adhesion, making FFF parts not suitable for most engineering applications. Post processing solutions, such as annealing, enable healing of these interlayers, thus approaching injection molded parts.

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While nonwoven fabrics have existed for several decades, their usage in personal protective equipment (PPE) has been met with a rapid surge of demands, in part due to the recent COVID-19 pandemic. This review aims to critically examine the current state of nonwoven PPE fabrics by exploring (i) the material constituents and processing steps to produce fibers and bond them, and (ii) how each fabric layer is integrated into a textile, and how the assembled textiles are used as PPE. Firstly, filament fibers are manufactured via dry, wet, and polymer-laid fiber spinning methods.

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Electrochemiluminescence (ECL) has an inherently low background and enables precise chemical reactions through electrical control. Here, we report an advanced ECL system, termed ECLipse (ECL in paired signal electrode). We physically separated ECL generation from target detection: These two processes were carried out in isolated chambers and coupled through an electrode.

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Smart textiles have gained great interest from academia and industries alike, spanning interdisciplinary efforts from materials science, electrical engineering, art, design, and computer science. While recent innovation has been promising, unmet needs between the commercial and academic sectors are pronounced in this field, especially for electronic-based textiles, or e-textiles. In this review, we aim to address the gap by (i) holistically investigating e-textiles' constituents and their evolution, (ii) identifying the needs and roles of each discipline and sector, and (iii) addressing the gaps between them.

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Thermoresponsive self-crimping polybutylene terephtlate (PBT)-based bicomponent fibers were fabricated by melt-spinning to serve as primary constituents for textiles, such as nonwoven battings, for an adaptive single insulting layer. Due to the intrinsically mismatching modulus and coefficient of thermal expansion (CTE), the fibers curl or straighten with temperature, similar to the concept of Timoshenko's bimetallic strip. Maximizing the curvature is driven by an optimum of fiber diameter, overall CTE, and fiber moduli, which are all affected by drawing ratio and, consequently, fiber's microstructure.

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Objective: This study aims to investigate compensatory rotational movements of the wrist joint in patients with proximal congenital radioulnar synostosis (CRUS), using a valid and reliable three-dimensional (3D) motion analysis technique.

Methods: A total of 26 patients (6 females, 14 males; mean age=15.3 years; and age range=6-32 years) who were diagnosed with unilateral proximal CRUS but were not operated were enrolled in this study.

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Many types of consumer-grade packaging can be used in material extrusion additive manufacturing processes, providing a high-value output for waste plastics. However, many of these plastics have reduced mechanical properties and increased warpage/shrinkage compared to those commonly used in three-dimensional (3D) printing. The addition of reinforcing materials can lead to stiffer parts with reduced distortion.

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Objectives: To compare the effectiveness and tolerability of micafungin versus posaconazole during chemotherapy-induced neutropenia in acute leukemia (AL) and myelodysplastic syndrome (MDS).

Methods: Patients with AL or MDS undergoing chemotherapy were randomized to open-label micafungin 100 mg intravenously daily or posaconazole suspension 400 mg orally twice daily until neutrophil recovery, up to 28 days. Patients were followed for 12 weeks.

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We report a facile fabrication of porous silicon nanofibers by a simple three-stage procedure. Polymer/silicon precursor composite nanofibers are first fabricated by electrospinning, a water-based spinning dope, which undergoes subsequent heat treatment and then reduction using magnesium to be converted into porous silicon nanofibers. The porous silicon nanofibers are coated with a graphene by using a plasma-enhanced chemical vapor deposition for use as an anode material of lithium ion batteries.

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Incorporation of nanorods (NRs) into a polymer matrix can greatly enhance the material properties, but the aggregation of NRs prevents the full realization of their potential. Using coarse-grained molecular dynamics simulation with the dissipative particle dynamics thermostat, we have systematically examined how key material and processing parameters, such as aspect ratio, particle diameter, rigidity and concentration of NR, polymer chain length, and shear rate can influence the placement and orientation of the self-aggregating NRs in a model polymer melt under shear. When compared with nanoparticles (NPs), the NRs tend to aggregate more severely even under strong shear flow.

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We have investigated the effect of nanorods on the symmetry breaking of a model diblock copolymer under cylindrical confinement using coarse-grained molecular dynamics. Unlike nanoparticles, nanorods can readily be interconnected with each other and also induce connection across self-assembly domains at much lower loading than nanoparticles. Such interconnecting nanorods, when incorporated within the nanofiber confined assembled block copolymer, have great potential for providing highly conductive pathways for energy applications, such as battery electrodes and separators.

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Mesoscale simulation, electrospinning and Raman scattering experiments have been carried out to demonstrate that examination and control of nanorod configuration in a polymer matrix under elongational flow and confinement can lead to enhanced sensing. First, coarse-grained molecular dynamics (CGMD) was employed to probe the diffusivity, orientation, and dispersion of nanorods in a model polymer melt under planar elongational flow. Compared to shear flow, elongational flow gives rise to enhanced dispersion and orientation of nanorods, which are predicted to be improved with increasing the aspect ratio of nanorods and polymer chain length.

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Antifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) polymer. The resulting fibers with amphiphilic polymer groups exhibited superior antifouling performance to the fibers without such groups.

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Multiaxial (triaxial/coaxial) electrospinning is utilized to fabricate block copolymer (poly(styrene-b-isoprene), PS-b-PI) nanofibers covered with a silica shell. The thermally stable silica shell allows post-fabrication annealing of the fibers to obtain equilibrium self-assembly. For the case of coaxial nanofibers, block copolymers with different isoprene volume fractions are studied to understand the effect of physical confinement and interfacial interaction on self-assembled structures.

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