Impact of Close Margins on Oral Cancer Outcomes According to the Oral Subsite.

Background: The prognostic significance of close margins in oral squamous cell carcinoma (OSCC) is controversial. We wished to investigate the impact of close margins on the risk of local recurrence (LR) in OSCC according to the oral subsite.

Methods: A retrospective cohort study of 342 OSCC patients undergoing primary surgical treatment was conducted.

Individual and interactive effects of amino acid and paracetamol on growth, physiological and biochemical aspects of L under drought conditions.

Drought stress poses a significant threat to (L.), impacting its growth, yield, and profitability. This study investigates the effects of foliar application of individual and interactive pharmaceutical (Paracetamol; 0 and 250 mg L) and amino acid (0 and 4 ml/L) on the growth, physiology, and yield of under drought stress.

Antimicrobial photodynamic therapy using a low-power 650 nm laser to inhibit oral activity: an in vitro study.

This study assessed the efficacy of antimicrobial photodynamic therapy (PDT) using a 650 nm diode laser combined with methylene blue (MB) as a photosensitizer to inhibit the growth of . Oral samples were collected from 75 patients diagnosed with oral thrush. was isolated and identified using traditional methods and the VITEK 2 YST system.

Eradication of mature biofilm from the isthmus region using Er, Cr: YSGG Laser as an activator of 2% chlorhexidine gluconate.

Background: Challenges in the root canal system, such as isthmus, may limit the action of endodontic equipment and irrigation solutions, so using laser agitation is recommended to upgrade the removal of microbial biofilm. The objective of this study is to assess the effectiveness of the laser in photon-induced photoacoustic streaming protocol agitation of 2% chlorohexidine gluconate in removing mature biofilm in complex root canal systems.

Material And Methods: Seventy-five mesial roots of the lower first and second molars were separated and cultivated with Enterococcus faecalis bacteria for 30 days (except for the negative control group samples).

Rebastinib attenuates liver injury following cecal ligation and puncture in male mice.

Sepsis remains a public health issue with high morbidity and mortality. Liver injury due to sepsis is associated with poor outcomes and an increased risk of death among septic patients. Rebastinib is a small molecule inhibiting the Tie2 receptor and vascular endothelial growth factor receptor-2 (VEGFR2).

Targeting VEGF using Bevacizumab attenuates sepsis-induced liver injury in a mouse model of cecal ligation and puncture.

Sepsis, a life-threatening condition resulting from an uncontrolled host response to infection, often leads to severe liver damage and remains a significant cause of mortality in critically ill patients despite advances in antibiotic therapy and resuscitation. Bevacizumab, a neutralizing antibody targeting vascular endothelial growth factor (VEGF), is approved for treating certain cancers. However, its potential impact on sepsis-related liver injury is not well understood.

Investigating the effect of Er,Cr:YSGG laser agitation of sodium hypochlorite on the removal of mature biofilm in the complex root canal systems using atomic force microscopy.

Background: Endodontic infections caused by remaining biofilm following disinfection with chemical fluids encourage secondary bacterial infection; hence, employing laser pulses to activate the fluids is advised to improve microbial biofilm clearance. This study investigated the performance of Er,Cr:YSGG laser in photon-induced photoacoustic streaming (PIPS) agitation of 5.25% sodium hypochlorite (NaOCl) to enhance the removal of mature Enterococcus faecalis (E.

Assessing disparities in medical students' knowledge and attitude about monkeypox: a cross-sectional study of 27 countries across three continents.

Background And Aims: The recent monkeypox (Mpox) outbreak confirmed by the World Health Organization (WHO) underscores the importance of evaluating the knowledge and attitude of medical students toward emerging diseases, given their potential roles as healthcare professionals and sources of public information during outbreaks. This study aimed to assess medical students' knowledge and attitude about Mpox and to identify factors affecting their level of knowledge and attitude in low-income and high-income countries.

Methods: A cross-sectional study was conducted on 11,919 medical students from 27 countries.

Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma.

Background: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC.

Methods: This was a retrospective study of 160 patients with T1/T2N0 tumours staged using TNM7 treated surgically.

COVID-19 Booster Doses: A Multi-Center Study Reflecting Healthcare Providers' Perceptions.

(1) Background: During 2019, the COVID-19 pandemic was threatening healthcare services and workers, and acquiring immunity was an option to stop or limit the burden of this pandemic. Herd immunity was a top priority worldwide as the virus was spreading rapidly. It was estimated that 67% of the total global population should be immunized against COVID-19 to achieve herd immunity.

The Effect of Early Feeding and Transporting Time from Hatcher to Farm On the Productive Performance and Carcass Traits of Broiler Chickens.

New researches suggest that an early feeding approach has a long-term influence on chick growth performance and nutrient metabolism. The present study was designed to determine the effect of early feeding and the time of chickens transferring from the hatchery to the field on broiler chickens' productive performance and carcass traits. Two hundred twenty-five chickens, one-day-old of broiler chickens Ross 308 with a mean live body weight of 45 g, were used and were randomly distributed to five treatments by 45 chickens per treatment with three replicates (15 chickens per replicate).

Debonding of LDSVs utilising Er,Cr:YSGG laser irradiation with fractional technique: an in vitro study.

Background: The removal of porcelain laminate veneers with rotary instruments could be accompanied by microfractures because differentiation of the veneer from the dental structure and resin cement is not a highly selective procedure. This can lead to scratches and overheating of the enamel and patient discomfort. Therefore, this in vitro research aimed to examine the effectiveness of the 2790 nm Er,Cr:YSGG laser utilizing a fractional technique to debond lithium disilicate veneer.

Iron enriched quinoa biochar enhances Nickel phytoremediation potential of L. by its immobilization and attenuation of oxidative stress: implications for human health.

The present study was performed to assess Ni-immobilization and the phytoremediation potential of sunflower by the application of quinoa stalks biochar (QSB) and its magnetic nanocomposite (MQSB). The QSB and MQSB were characterized with FTIR, SEM, EDX, and XRD to get an insight of their surface properties. Three-week-old seedlings of sunflower were transplanted to soil spiked with Ni (0, 15, 30, 60, 90 mg kg), QSB and MQSB (0, 1, and 2%) in the wire house under natural conditions.

The influence of pulse duration and exposure time of Er,Cr:YSGG laser on lithium disilicate laminate debonding, an study.

Problem Statement: Grinding restorations, such as veneers, with rotary instruments, is the conventional removal approach. It may be accompanied by micro-fractures that affect the adjacent healthy dental structures. Differentiation of the veneer from the dental structure, as well as the resin cement, is not a highly selective procedure when rotary instruments are used.

PHYSIOLOGICAL AND HISTOLOGICAL STUDY OF THE CALCIUM OXIDE NANOPARTICLES EFFECT ON THE TESTIS OF MALE WISTER RATS.

Objective: The aim: The study carried out to determine the effect of the Calcium Oxide Nano Particles on the male rats. In this study were used calcium oxide nano powder to enhancing apoptosis in germ cells and disrupting hormonal regulation of reproductive processes in the adult male rats.

Patients And Methods: Materials and methods: The experiment using nine male rats, were distributed into three groups.

Towards rainbow portable Cytophone with laser diodes for global disease diagnostics.

In vivo, Cytophone has demonstrated the capability for the early diagnosis of cancer, infection, and cardiovascular disorders through photoacoustic detection of circulating disease markers directly in the bloodstream with an unprecedented 1,000-fold improvement in sensitivity. Nevertheless, a Cytophone with higher specificity and portability is urgently needed. Here, we introduce a novel Cytophone platform that integrates a miniature multispectral laser diode array, time-color coding, and high-speed time-resolved signal processing.

Comparison of royal college of pathologists and college of american pathologists definition for positive margins in oral cavity squamous cell carcinoma.

Background: Pathological margin assessment is an essential component of surgical management of oral cavity squamous cell carcinoma (OCSCC), however, in many studies, variable definitions of involved margins have been used. The purpose of the present study was to compare the prognostic ability of involved margins according to Royal College of Pathologists (RCPath) and College of American Pathologists (CAP) guidance.

Methods: Retrospective study of 300 patients with previously untreated OCSCC undergoing definitive surgical management.

Smear Layer Removal from the Apical Third Using the Er,Cr:YSGG Photon-induced Photoacoustic Streaming.

Introduction: The purpose was to study the influence of Erbium,Chromium:Yttrium Scandium Gallium Garnet (Er,Cr:YSGG) laser at short pulse duration on smear layer removal from apical root third.

Materials And Methods: Twenty-four single-rooted mandibular premolars were used. The roots length was cut to 14 mm and instrumented using the Protaper Gold system to size 40/0.

Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.

Purpose: The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium.

Methods: This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center.

Prognostic performance of TNM8 staging rules in oral cavity squamous cell carcinoma.

Background: Two major changes to the staging of oral cavity squamous cell carcinoma (OCSCC) were adopted in TNM8: (1) depth of invasion is now used for T staging and (2) extranodal extension for N staging. The aim of this study was to evaluate if TNM8 stratifies OCSCC patients more accurately than TNM7 based on overall survival (OS) statistics and hazard discrimination.

Methods: Retrospective study of 297 patients with OCSCC who underwent surgery at our institution.