Tranexamic Acid in Pregnant Women With Placenta Previa: A Double-Blind, Multicenter Randomized Clinical Trial.

Aims: To determine the effectiveness of tranexamic acid (TXA) in reducing vaginal bleeding, extending pregnancy duration, and enhancing perinatal outcomes in pregnant women with placenta previa.

Methods: A multicenter, randomized, double-blind clinical trial was conducted at three maternity teaching hospitals in Iraq's Kurdistan region, Azadi Hospital in the north of Iraq, and Al-Azhar University Hospital in Egypt on 146 women with placenta previa. Participants were randomly assigned to two interventional groups in a 1:1 ratio to receive either TXA or Dextrose 5% water (D5W).

Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center.

Purpose: Trauma is a significant health concern globally and is one of the leading causes of illness and death. The laparoscopic approach has gained popularity in trauma care since its inception, becoming increasingly favored for both diagnostic and therapeutic purposes. This study aims to reduce unnecessary laparotomies and assess the effectiveness of laparoscopy in managing patients with blunt abdominal trauma.

Impact of Antimicrobial Therapy on Mortality and Readmission in Multidrug-Resistant Pseudomonas Infections: A Retrospective Study at Dammam Medical Complex.

Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a significant treatment challenge, necessitating effective antimicrobial options. This retrospective, single-center cohort study was conducted at Dammam Medical Complex and aimed to evaluate the comparative effectiveness and safety of ceftazidime-avibactam (CAZ-AVI), ceftolozane-tazobactam (C-T), and meropenem and colistin in treating MDR P. aeruginosa infections.

Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.

Objective: Myo-inositol (Myo-Ins), the most abundant form of inositol, is an antioxidant and plays a crucial role in the development and reproduction of mammals and humans. However, information elucidating the role of Myo-Ins in porcine embryonic development after parthenogenetic activation (PA) is still lacking. Therefore, we investigated the effect of Myo-Ins on porcine embryos and its underlying mechanisms.

Role of Strong Opioids in an Effective Discharge for Lower-Limb Large Joint Arthroplasty Patients: A Patient-Based Analysis.

Background/objective: Adequate postoperative analgesics are an essential element in the recovery and rehabilitation of large joint lower-limb arthroplasty patients in their acute postoperative phase. In this study, we will establish that strong opioids like morphine should be included as postoperative analgesics to improve patient satisfaction.  Material: This retrospective cross-sectional study was conducted in the Arthroplasty Ward, Trauma, and Orthopaedics Department in a district general hospital of the United Kingdom.

A comparison of freeze- and air-dried chitosan salicylaldehyde/calcium oxide biocomposites for optimized removal of acid red 88 dye.

Chitosan salicylaldehyde/calcium oxide nanoparticle (CS-SL/CaO) was synthesized by hydrothermal process and isolated via different drying processes, namely, air-drying (AD) and freeze-drying (FD). The physicochemical properties of freeze-dried CS-SL/CaO nanoparticle (CS-SL/CaO-FD) and air-dried CS-SL/CaO nanoparticle (CS-SL/CaO-AD) were compared. In particular, the adsorption properties reveal that the specific surface area of CS-SL/CaO-FD increased by ca.

Design of composite chitosan/algae/zeolite by freeze- or air-drying: A comparative adsorbent analysis for optimized removal of brilliant green dye.

A bio-composite material was developed that contains chitosan, food-grade algae, and zeolite for the removal of brilliant green (BG) dye. The synthesized bio-composite was dried via two different methods (air-drying; AD, and freeze-drying; FD). The physicochemical characterization of air-dried chitosan-algae-zeolite (Cs-Alg-Zl-AD) and freeze-dried chitosan-algae-zeolite (Cs-Alg-Zl-FD) were investigated by spectroscopy (FTIR, SEM-EDX, and XPS), diffraction (XRD), surface charge via pH, specific surface area (SSA) and elemental analyses.

Freeze-drying synthesis of mesoporous magnetic grafted chitosan/calcium oxide nanoparticle for remazol brilliant blue dye removal: A statistical optimization.

Herein, a mesoporous magnetic chitosan-salicylaldehyde/calcium oxide nanoparticle (CS-SL/CaO/FeO) biocomposite adsorbent that was prepared via freeze-drying. The CS-SL/CaO/FeO was utilized for the adsorption of ramazol brilliant blue (RBB) dye from aqueous solution. The physicochemical properties of the CS-SL/CaO/FeO were evaluated using diverse characterization techniques, including BET, XRD, FTIR, FESEM-EDX, CHNS, and pH.

THE EFFECT OF PRE-MEDICATION WITH ORAL STEROIDS ON INTRA-OPERATIVE BLEEDING IN PATIENTS WITH CHRONIC RHINOSINUSITIS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY.

Background: An inflammation of the nasal and paranasal sinus mucosa that lasts longer than three months is known as chronic rhinosinusitis. When corticosteroids and other medicinal treatments fail to relieve a patient's symptoms, then functional endoscopic sinus surgery (FESS) is a commonly performed procedure to alleviate the symptoms. The aim of the study was to evaluate the impact of oral steroids given prior to surgery on intraoperative bleeding in patients having functional endoscopic sinus surgery for chronic rhinosinusitis.

Exploring key factors associated with falls in people with multiple sclerosis: The role of trunk impairment and other contributing factors.

Background: Falls are a common and consequential concern for persons with multiple sclerosis (PwMS), with trunk impairment frequently observed even in the early stages of the disease. However, the relationship between falls and trunk impairment using the trunk impairment scale in this population remains unclear. This study aims to explore this association and identify potential factors contributing to falls in PwMS.

Pyridoxine-dependent epilepsy caused by an ALDH7A1 mutation in an infant girl: the first case report in Syria.

Background: Pyridoxine-dependent epilepsy is primarily characterized by early-onset refractory seizures. This condition can be caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency due to a mutation in the ALDH7A1 gene, leading to the accumulation of certain substances that impact the production of various brain neurotransmitters and enzymes.

Case Presentation: Our report presents the first documented case of pyridoxine dependency in Syria.

Assessment of CD40L and TSAB serum level in Graves disease patients.

Background: The autoimmune disorder known as Graves' disease. The condition is due to the binding of thyroid-stimulating immunoglobulins to the thyrotropin receptor located on the thyroid gland. The result is an excess of thyroidal hormones.

The Impact of Tobacco Smoking on Systemic Sclerosis, Idiopathic Inflammatory Myositis, and Systemic Lupus Erythematosus.

This narrative review aims specifically to explore the relationship between tobacco exposure and systemic sclerosis (SSc), idiopathic inflammatory myositis (IIM), and systemic lupus erythematosus (SLE). Relevant articles were obtained by searching key terms such as "tobacco," "smoking," "scleroderma," "myositis," "lupus," and "Sjögren's" in PubMed and Google Scholar databases. The selected articles ranged from the years 2010 to 2023.

Advancements and Challenges in Personalized Therapy for -Mutant Melanoma: A Comprehensive Review.

Over the past several decades, advancements in the treatment of -mutant melanoma have led to the development of inhibitors, /MEK inhibitor combinations, anti-PD-1 therapy, and anti-CTLA4 therapy. Although these therapies have shown substantial efficacy in clinical trials, their sustained effectiveness is often challenged by the tumor microenvironment, which is a highly heterogeneous and complex milieu of immunosuppressive cells that affect tumor progression. The era of personalized medicine holds substantial promise for the tailoring of treatments to individual genetic profiles.

Proximal policy optimization-based reinforcement learning approach for DC-DC boost converter control: A comparative evaluation against traditional control techniques.

This article proposes a proximal policy optimization (PPO)-based reinforcement learning (RL) approach for DC-DC boost converter control that is compared with traditional control methods. The performance of the PPO algorithm is evaluated using MATLAB Simulink co-simulation, and the results demonstrate that the most efficient approach for achieving short settling time and stability is to combine the PPO algorithm with a reinforcement learning-based control method. The simulation results show that the control method based on RL with the PPO algorithm provides step response characteristics that outperform traditional control approaches, thereby enhancing DC-DC boost converter control.

Hydrothermal fabrication of composite chitosan grafted salicylaldehyde/coal fly ash/algae for malachite green dye removal: A statistical optimization.

In this study, chitosan grafted salicylaldehyde/coal fly ash/algae (Chi-SL/CFA/Alg) was synthesized by assistance of hydrothermal process to be an effective adsorbent to remove cationic dye (malachite green: MG) from water. The physicochemical properties of the Chi-SL/CFA/Alg biomaterial were examined using SEM-EDX, pH, specific surface area (BET), and FTIR analyses. The optimization process of the adsorption operation parameters for MG removal by Chi-SL/CFA/Alg were optimized using a Box-Behnken design (BBD).

Comparative analysis of pediatric pulmonary and extrapulmonary tuberculosis: A single-center retrospective cohort study in Syria.

Background: Tuberculosis (TB) is a global public health challenge, contributing significantly to morbidity and mortality worldwide. This research aims to investigate the epidemiology, clinical characteristics, diagnostic methods, and early mortality rate among pediatric patients with pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) who were admitted to a hospital in Syria.

Methods: This retrospective cohort study was conducted at the University Children's Hospital in Syria, involving pediatric patients diagnosed with TB between January 2013 and January 2023.

Preparation for implementation of evidence-based practices in urban schools: A shared process with implementing partners.

Background: Shifting organizational priorities can negatively affect the sustainment of innovations in community settings. Shifting priorities can present barriers to conducting clinical research in schools if a misalignment occurs between school district priorities and the aims of the study. Often this misalignment occurs due to a shift during the period between when the study is submitted for funding and when research activities begin.

Early Neonatal Shock: Case Report and Lessons Learned in Management.

We report a case of a neonate, delivered by C-section, that rapidly developed respiratory compromise and hemodynamic instability prompting admission to critical care. Urgent cardiology assessment with echocardiography revealed severe systolic dysfunction from localized myocardial ischemia and pulmonary hypertension. Their management progressively escalated, eventually requiring inotropic support.