Publications by authors named "Javier de la Fuente"

: Rock climbing is becoming more popular, leading to an increased focus on diagnosing and treating related injuries. Finger pulley and flexor tendon injuries are common among climbers, with the A2 pulley being the most frequently affected. High-resolution ultrasound (US) is the preferred method for detecting pulley injuries.

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  • Non-cognitive skills, like motivation and self-regulation, are genetic traits that affect academic success, and their impact increases as children grow from ages 7 to 16.
  • A study involving over 10,000 children from England and Wales found that non-cognitive skills became more closely linked to academic achievement as the children developed.
  • Analyses showed that the genetic influence of non-cognitive skills on academic performance is not solely due to differences in family environments, suggesting a complex interaction between genes and environment.
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The genus is distributed mainly in temperate forests and establishes ectomycorrhizal associations with angiosperms and gymnosperms. Studies on this genus are scarce in México. A visual, morphological, and molecular (ITS-LSU) description of , , , , , , , , , , and was carried out in this work, associated with , , and .

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Boletes are one of the most common groups of fungi in temperate, subtropical, and tropical ecosystems. In Mexico, the northern region has mainly been explored in terms of bolete diversity. This study describes a new genus and seven new species based on macromorphological, micromorphological, molecular, phylogenetic, and ecological data.

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Among Boletales, the family Boletaceae has the highest diversity worldwide. Additionally, this fungal group has great ecological relevance because it not only includes mainly ectomycorrhizal but also saprotrophic species. Furthermore, some species are used as food and have sociocultural and economic importance worldwide.

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The tropical montane cloud forest is the most diverse and threatened vegetation type in Mexico. In the last decade, the number of described Ascomycetes species has notably increased, reaching more than 1300 species. This study describes six new species based on their molecular and morphological characteristics.

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Article Synopsis
  • * This study measured the tendon-to-bone distance (TBD) using 30 fingers categorized into five groups based on the severity of simulated A2 pulley tears, revealing significant increases in TBD with longer ruptures, but no notable differences within partial rupture groups.
  • * The findings indicate that a TBD of 1.6 mm is the minimum for diagnosing a partial A2 pulley rupture, while values above 3 mm can indicate a high-grade partial rupture or a complete rupture, highlighting the need for clearer diagnostic thresholds in the literature
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Background: The masseteric nerve is one of the main options to neurotize free muscle flaps in irreversible long-term facial paralysis. Several preoperative skin-marking techniques for the masseteric nerve have been proposed to limit the surgical dissection area, shorten the surgical time, and enable a safer dissection. However, these have shown variability among them, and cannot visualize the nerve preoperatively.

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Two new species of sequestrate fungi are described from south Mexico based on morphological and molecular evidences. Here we describe characterized by the yellowish mycelial mat, dull blue gleba and ascospores of 9.7-11.

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The tropical montane cloud forest in Mexico is the most diverse and threatened ecosystem. Mexican macrofungi numbers more than 1408 species. This study described four new species of Agaricomycetes (, , , ) based on molecular and morphological characteristics.

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Article Synopsis
  • Noncognitive skills, like motivation and self-regulation, are partially inherited and play a significant role in predicting academic success, even more so than cognitive skills.
  • A study of over 10,000 children in England and Wales showed that the influence of noncognitive skills on academic achievement grows as children age, from 7 to 16 years old.
  • Genetic analyses suggest that the impact of noncognitive traits on academic performance strengthens over time, and findings indicate that this relationship isn't solely due to environmental factors, highlighting the interplay between genetics and development in education.
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Article Synopsis
  • Noncognitive skills like motivation and self-regulation are shown to predict academic success even more than cognitive skills, but the influence of genetics and the environment on this relationship is still not fully understood.
  • A study involving over 10,000 children in England and Wales demonstrated that noncognitive skills become more significant in predicting academic achievement as children grow from ages 7 to 16.
  • Using genetic methods, the research revealed that the genetic influence of noncognitive skills on academic achievement increases with age, highlighting the complex interactions between genetics and the environment in academic development.
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Understanding the neurodegenerative mechanisms underlying cognitive decline in the general population may facilitate early detection of adverse health outcomes in late life. This study investigates genetic links between brain morphometry, ageing and cognitive ability. We develop Genomic Principal Components Analysis (Genomic PCA) to model general dimensions of brain-wide morphometry at the level of their underlying genetic architecture.

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Two new species of are described from south Mexico based on morphological and molecular evidence. is characterized by the caespitose ascomata, rough and coiled paraphyses and the ascospores with 9-11 septa. is characterized by the capitate ascomata, clavate and straight paraphyses and the ascospores with 10-12 septa.

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The human skeletal form underlies our ability to walk on two legs, but unlike standing height, the genetic basis of limb lengths and skeletal proportions is less well understood. Here we applied a deep learning model to 31,221 whole body dual-energy X-ray absorptiometry (DXA) images from the UK Biobank (UKB) to extract 23 different image-derived phenotypes (IDPs) that include all long bone lengths as well as hip and shoulder width, which we analyzed while controlling for height. All skeletal proportions are highly heritable (∼40-50%), and genome-wide association studies (GWAS) of these traits identified 179 independent loci, of which 102 loci were not associated with height.

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Functional genomic methods are needed that consider multiple genetically correlated traits. Here we develop and validate Transcriptome-wide Structural Equation Modeling (T-SEM), a multivariate method for studying the effects of tissue-specific gene expression across genetically overlapping traits. T-SEM allows for modeling effects on broad dimensions spanning constellations of traits, while safeguarding against false positives that can arise when effects of gene expression are specific to a subset of traits.

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Background: Single nucleotide polymorphism-based heritability is a fundamental quantity in the genetic analysis of complex traits. For case-control phenotypes, for which the continuous distribution of risk in the population is unobserved, observed-scale heritability estimates must be transformed to the more interpretable liability scale. This article describes how the field standard approach incorrectly performs the liability correction in that it does not appropriately account for variation in the proportion of cases across the cohorts comprising the meta-analysis.

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Background: Tetanus disease is caused by Clostridium tetani, an anaerobe bacteria found in dust and soil. Once reached human body through damaged tissues, C. tetani releases several neurotoxins which block the inhibitory function, leading to an increased muscle tone, ultimately causing respiratory failure.

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Switching dual therapy with dolutegravir (DTG) plus rilpivirine (RPV) was assessed in the SWORD-1 and SWORD-2 studies. Real-life data regarding the immunological impact of this approach on CD4+ and CD8+ T lymphocyte counts and the CD4/CD8 ratio are scarce. We evaluated this strategy on the basis of clinical practice data.

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Recent meta-analyses combining direct genome-wide association studies (GWAS) with those of family history (GWAX) have indicated very low SNP heritability of Alzheimer's disease (AD). These low estimates may call into question the prospects of continued progress in genetic discovery for AD within the spectrum of common variants. We highlight dramatic downward biases in previous methods, and we validate a novel method for the estimation of SNP heritability via integration of GWAS and GWAX summary data.

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Article Synopsis
  • Theories of adult cognitive development differentiate between fluid abilities, which involve active problem-solving, and crystallized abilities, which relate to knowledge application.
  • Fluid abilities generally decline with age, while crystallized abilities tend to improve or remain stable as individuals grow older.
  • New research reveals a strong correlation between changes in fluid and crystallized abilities, suggesting that individuals who experience significant declines in fluid abilities may simultaneously see smaller gains or losses in crystallized abilities, challenging existing ideas about compensatory mechanisms in cognitive development.
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In this work, we present the results of a comparison of simple artificial neural network (FFNN) designs intended to identify infant bottle-feeding events and appropriate feeding volume recording intervals using accelerometer data recorded from a custom designed "Smart Bottle" system. To properly identify and distinguish these events with an accuracy of 99.8%, while accommodating the constraints of the deployment environment, two concurrent FFNNs were implemented.

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The second part of the Guidelines and Recommendations for Musculoskeletal Ultrasound (MSUS), produced under the auspices of EFSUMB, following the same methodology as for Part 1, provides information and recommendations on the use of this imaging modality for joint pathology, pediatric applications, and musculoskeletal ultrasound-guided procedures. Clinical application, practical points, limitations, and artifacts are described and discussed for every joint or procedure. The document is intended to guide clinical users in their daily practice.

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