Publications by authors named "Javier Zamarreno"
Article Synopsis
- * In eukaryotes, this process involves DNA polymerase Pol ∂, 5' Flap endonuclease Fen1, and DNA ligase I, all coordinated by the sliding clamp PCNA.
- * The study highlights the role of the deubiquitylase Ubp10 in budding yeast, which promotes the timely ligation of Okazaki fragments by facilitating the release of PCNA through deubiquitylation of lysine 164.
Reactive oxygen species (ROS) are an important source of cellular damage. When ROS intracellular levels increase, oxidative stress takes place affecting DNA stability and metabolic functions. To prevent these effects, stress-activated protein kinases (SAPKs) delay cell cycle progression and induce a transcriptional response that activates antioxidant mechanisms ensuring cell adaptation and survival.
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