Influence of STAT4 gene polymorphisms in the pathogenesis of endometriosis.

The STAT4 gene is vital to signaling pathways in the immune response. Immunological alterations are involved in the pathogenesis of endometriosis, and STAT4 polymorphisms may be linked to disease development. This study's aim is to evaluate the possible association between four STAT4 polymorphisms (rs7601754/G > A, rs11889341/C > T, rs7574865/T > G, and rs7582694/C > G) and the pathogenesis of endometriosis in Brazilian women.

Controversies of the hormonal conservative treatment of endometrial cancer.

Background: Hysterectomy plus salpingo-oophorectomy represents the standard treatment for patients with well-differentiated endometrial cancer (EC) limited to the endometrium. It is estimated that over 5% of EC are diagnosed in nulliparous women aged 35-44 years. In addition, EC can affect obese women with diabetes, hypertension and other comorbidities increasing the surgical risk.

Three-dimensional angioultrasonography for the prediction of malignancy in ovarian masses.

Objective: To determine the efficacy of the angiographic indexes of 3D power Doppler angiography (3D-PDA) for the diagnosis of malignancy in complex ovarian masses.

Methods: A prospective, observational study of 72 patients with complex adnexal mass.

Results: In the morphological study, 3D ultrasound showed sensitivity, specificity, PPV, NPV, PLHR and NLHR of 84.

[Differential diagnosis of Dandy-Walker syndrome different presentations].

Objective: Dandy-Walker syndrome is a set of abnormalities of the posterior fossa including three modalities: classic Dandy-Walker malformation, Dandy-Walker variant and mega-cisterna magna. Our objective is clarify the differential diagnosis among these entities.

Material And Method: Descriptive and retrospective study of Dandy-Walker cases diagnosed at our Department during the last five years plus a review of the related Medical literature.

[Reproducibility of the fetal nasal bone measurement by means of bidimensional and three-dimensional ecography during the second trimester of the pregnancy].

Aims: The utility of the valuation-measurement of the nasal bone in the prognosis of chromosomopaties during the second trimester of the pregnancy is demonstrated.

Objective: To evaluate the repeatability of nasal bone measurement during second trimester with bidimensional and three-dimensional sonography.

Material And Method: Nasal bone was measured in 50 single pregnancies.

[Fetal chylothorax. Is prenatal treatment beneficial?].

We report a case of fetal chylothorax handled with intrauterine treatment, which finally died. Diagnosis, treatment and evolution are reviewed. Characteristics of the disease are described and treatment options are discussed.

Long-term use of oral contraceptives increases the risk of miscarriage.

In this prospective, case-control study, a step-wise logistic regression model was used to examine the relationship between the consumption of oral contraceptives before pregnancy and the potential increase in the risk of miscarriage. Consumption of oral contraceptives for more than 2 years before pregnancy is associated with a higher risk of miscarriage.

Risk factors for low birth weight: a review.

Low birth weight (LBW) is one of the main predictors of infant mortality. The global incidence of LBW is around 17%, although estimates vary from 19% in the developing countries (countries where it is an important public health problem) to 5-7% in the developed countries. The incidence in Spain in the decade 1980-1989 was about 5.