Publications by authors named "Javier Subiza"
Background: Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose of mannan-allergoid conjugates derived from grass pollen ( and ) administered via either the subcutaneous or sublingual route.
Methods: A randomized, double-blind, placebo-controlled trial with a double-dummy design was conducted, involving 162 participants across 12 centers in Spain.
Influence of environmental drivers on allergy to pollen grains in a case study in Spain (Madrid): meteorological factors, pollutants, and airborne concentration of aeroallergens.
Environ Sci Pollut Res Int
October 2021
Article Synopsis
- The study aimed to analyze airborne levels of specific grass pollen allergens (Phl p 1 and Phl p 5) and their correlation with symptoms among patients with grass allergies throughout and outside the pollen season.
- Various pollen and allergen samplers were used to collect data over a period of over a year, during which 23 patients reported their symptoms electronically.
- Results showed significant variations in pollen levels and allergen potency, with notable correlations between allergens, climate factors, and symptom severity, particularly highlighting the clinical importance of Phl p 1 even outside the pollen season.
Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1.
J Allergy Clin Immunol
August 2016
Background: Allergen immunotherapy (AIT) is the only curative treatment for allergy. AIT faces pitfalls related to efficacy, security, duration, and patient compliance. Novel vaccines overcoming such inconveniences are in demand.
View Article and Find Full Text PDFBackground: Since barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis.
Methods: Randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic rhinitis or rhinoconjunctivitis due to sensitization to birch, grass or olive tree pollens received treatment with topical microemulsion or placebo during the pollen seasons. Efficacy variables included scores in the mini-RQLQ questionnaire, number and severity of nasal, ocular and lung signs and symptoms, need for symptomatic medications and patients' satisfaction with treatment.