Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry.

This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. The water samples were analyzed by ultra-high-performance liquid chromatography coupled to hybrid triple quadrupole mass spectrometer (UHPLC-MS/MS QqQ). Taking profit of the increasing sensitivity of nowadays tandem mass spectrometers, direct sample injection of large volumes has been an attractive alternative to pre-concentration steps.

Complete fixed prostheses over implants in patients with oral epidermolysis bullosa.

Purpose: This study was conducted to evaluate the feasibility of placing fixed prostheses over endosseous implants in edentulous patients with recessive dystrophic epidermolysis bullosa.

Patients And Methods: Three cases of dental implants with fixed prostheses are presented. All 3 patients had marked oral involvement, with devastating alterations in the soft and hard tissues.