Publications by authors named "Javier Navarrete-Navarro"
Article Synopsis
- * Interventional cardiology plays a vital role in managing HF, providing various percutaneous treatments for both acute and chronic conditions.
- * There is a lack of robust research on these interventions, highlighting the need for high-quality trials and international registries to better understand which patients benefit the most.
Background: Lumenless leads (LLLs) are widely used for left bundle branch area pacing (LBBAP). Recently, stylet-driven leads (SDLs) have also been used for LBBAP.
Objective: The purpose of this study was to evaluate the acute performance of SDLs during LBBAP in comparison with LLLs.
Cardiac resynchronization therapy (CRT) via biventricular pacing (BiVP-CRT) is considered a mainstay treatment for symptomatic heart failure patients with reduced ejection fraction and wide QRS. However, up to one-third of patients receiving BiVP-CRT are considered non-responders to the therapy. Multiple strategies have been proposed to maximize the percentage of CRT responders including two new physiological pacing modalities that have emerged in recent years: His bundle pacing (HBP) and left bundle branch area pacing (LBBAP).
View Article and Find Full Text PDFIntroduction: Implant procedure features and clinical implications of left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP) have not been yet fully described. We sought to compare two different left bundle branch area pacing (LBBAP) implant strategies: the first one accepting LVSP as a procedural endpoint and the second one aiming at achieving LBBP in every patient in spite of evidence of previous LVSP criteria.
Methods: LVSP was accepted as a procedural endpoint in 162 consecutive patients (LVSP strategy group).
Background/aim: In chronic liver disease, various immune cell subsets exert pro or anti-tumour effects by releasing reactive oxygen and nitrogen species (ROS, RNS). Here, we evaluated the oxidative and nitrosative pattern in peripheral blood leukocyte subpopulations of early hepatocellular carcinoma (HCC) patients compared with HCC-free cirrhotic patients.
Materials And Methods: Venous blood samples from 18 HCC-free cirrhotic patients and 17 early stage HCC patients were collected to determine ROS, RNS and reduced glutathione levels in isolated leukocytes analyzed by flow cytometry.
Aim: To evaluate the effects of asymmetric dimethylarginine (ADMA) in renal arteries from portal hypertensive and cirrhotic rats.
Methods: Rat renal arteries from Sham ( = 15), pre-hepatic portal hypertension (PPVL; = 15) and bile duct ligation and excision-induced cirrhosis (BDL; = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA (10-10 mol/L), an endogenous inhibitor of nitric oxide (NO) synthase. Concentration-response curves to acetylcholine (1 × 10-3 × 10 mol/L) were determined in precontracted renal artery segments with norepinephrine in the absence and in the presence of ADMA.