Sexual dysfunction in female patients with anal cancer treated with curative intent: A systematic review of the literature.

Background And Purpose: Patients with anal squamous cell carcinoma (SCC) are treated with sphincter-preserving radiation therapy and concurrent chemotherapy, achieving excellent oncologic outcomes. Patients, however, may experience treatment-related morbidity including sexual dysfunction. The objective of this systematic review was to review the literature on sexual dysfunction in female patients treated for anal cancer and to identify knowledge gaps.

First reported case of Robinsoniella peoriensis pyometra and bloodstream infection: A case report and review of the literature.

We report on a 47-year-old woman with jejunal adenocarcinoma and concurrent endometrial cancer, admitted with sepsis. Uterine fluid and blood cultures were positive for Robinsoniella peoriensis. This is the first case report of Robinsoniella peoriensis in Canada.

Risk Factors Associated with Uterine Rupture and Dehiscence: A Cross-Sectional Canadian Study.

Objective:  To compare maternal and perinatal risk factors associated with complete uterine rupture and uterine dehiscence.

Methods:  Cross-sectional study of patients with uterine rupture/dehiscence from January 1998 to December 2017 (30 years) admitted at the Labor and Delivery Unit of a tertiary teaching hospital in Canada.

Results:  There were 174 (0.

The Evolution of Clinically Aggressive Triple-Negative Breast Cancer Shows a Large Mutational Diversity and Early Metastasis to Lymph Nodes.

In triple-negative breast cancer (TNBC), only 30% of patients treated with neoadjuvant chemotherapy achieve a pathological complete response after treatment and more than 90% die due to metastasis formation. The diverse clinical responses and metastatic developments are attributed to extensive intrapatient genetic heterogeneity and tumor evolution acting on this neoplasm. In this work, we aimed to evaluate genomic alterations and tumor evolution in TNBC patients with aggressive disease.

Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic.

Triple-negative breast cancer (TNBC) presents a marked diversity at the molecular level, which promotes a clinical heterogeneity that further complicates treatment. We performed a detailed whole exome sequencing profile of 29 Mexican patients with long follow-up TNBC to identify genomic alterations associated with overall survival (OS), disease-free survival (DFS), and pathologic complete response (PCR), with the aim to define their role as molecular predictive factors of treatment response and prognosis. We detected 31 driver genes with pathogenic mutations in (53%), (27%), (9%), (9%), and (9%), and 16 operative mutational signatures.

Factors associated with use of hormone therapy after preventive oophorectomy in BRCA mutation carriers.

Objective: Bilateral salpingo-oophorectomy (oophorectomy) is recommended to women with a germline BRCA1 or BRCA2 mutation before natural menopause to prevent ovarian and fallopian tube cancer. The adverse effects of early surgical menopause are well established. Although many of the side effects can be ameliorated by the use of hormone therapy (HT); use of HT in this group of predominantly young patients remains suboptimal.

Radical trachelectomy: a fertility-sparing option for early invasive cervical cancer.

For the past 15 years gynecological oncologists have been seeking ways to preserve woman's fertility when treating invasive cervical cancer. For some women with small localized invasive cervical cancers, there is now hope for pregnancy after treatment. Many cases of cervical cancer are diagnosed in young woman who wish to preserve their fertility.

[Robotic-assisted gynecological surgeries: a series of the first 14 cases].

Purpose: To present the outcomes of the first 14 robotic-assisted gynecological surgeries from Israel.

Method: A total of 14 patients, who underwent robotic-assisted gynecological surgeries including total and subtotal hysterectomies with and without bilateral salpingo-oopherectomy, as well as one unilateral salpingo-oopherectomy and omental biopsy, were included in this study. Patients' demographics, surgical procedures, operative and postoperative complications, hospital stay, conversion to laparotomy, time data including all operative times and pathological specimen's weight were recorded.

Uterine sarcoma: prognostic factors and treatment evaluation.

Background: Uterine sarcoma constitutes a highly malignant group of uterine tumors. It accounts for 2-6% of uterine malignancies and its incidence is 1.7 in 100,000 women.

Fertility in women after surgical treatment of nonepithelial ovarian tumors.

Conservative treatment is an acceptable option for women with nonepithelial ovarian tumors who wish to preserve fertility.