Cannabis and Public Health: A Study Assessing Regular Cannabis Users Through Health Indicators.

An increasing number of countries are deciding to regulate the medicinal and/or recreational use of cannabis ( L.). However, there is a lack of information on the impact of regular consumption of this substance on public health.

Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate.

N,N-dimethyltryptamine (DMT) is a potent psychedelic naturally produced by many plants and animals, including humans. Whether or not DMT is significant to mammalian physiology, especially within the central nervous system, is a debate that started in the early 1960s and continues to this day. This review integrates historical and recent literature to clarify this issue, giving special attention to the most controversial subjects of DMT's biosynthesis, its storage in synaptic vesicles and the activation receptors like sigma-1.