Publications by authors named "Javier Gonzalez-Damian"
Article Synopsis
- Amphotericin B is a powerful antifungal, but its use is limited due to high toxicity, prompting research for safer derivatives.
- The study focused on the molecular mechanism of polyene action, examining various scientific aspects to develop a new, safer version called L-histidine methyl ester of Amphotericin B.
- This new derivative exhibits similar antifungal action as the original but shows reduced dimerization, leading to greater selectivity and improved safety in preclinical tests.
Amphotericin B is an antibiotic that forms ion channels in the membrane of a host cell. The change in permeability produced by these channels is greatly improved by sterols; nevertheless, the single channel conductivity remains invariant. Hence, it is proposed that sterols do not act directly, but rather through the modulation of the membrane phase.
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