Publications by authors named "Javier Francisco Viada Bris"
Background/objectives: The paediatric reference range of fecal calprotectin (FC) has not been decisively established and previous studies show a wide within-age variability, suggesting that other factors like anthropometric data or type of feeding can influence FC. Our aims were to establish the normal levels of FC in healthy children grouped by age and analyze whether sex, gestational age, birth weight, type of delivery, type of feeding, or anthropometric data influence FC values.
Methods: This multicentre, cross-sectional, and observational study enrolled healthy donors under 18 years of age who attended their Primary Health Care Centre for their routine Healthy Child Program visits.
Article Synopsis
- Exclusive enteral nutrition (EEN) is more effective than corticosteroids for achieving mucosal healing in children with Crohn's disease, without the negative side effects of steroids.
- A study covering 222 newly diagnosed pediatric patients found that 83% achieved clinical remission after an average of 8 weeks of EEN, with significant reductions in faecal calprotectin levels.
- Factors predicting a better response to EEN include specific scores on the Crohn's disease activity index, lower calprotectin levels, elevated CRP, and ileal involvement, suggesting EEN should be first-line treatment for pediatric Crohn's disease.
Hemolytic-uremic syndrome (HUS) is defined as the triad of nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure, in which the underlying lesions are mediated by systemic thrombotic microangiopathy (TMA). The atypical HUS (aHUS) can be considered a subtype of HUS that is rare in childhood and has a worse prognosis. Recent findings have established that the TMA in aHUS are consequences of the disregulation of the complement activation, leading to endotelial damage mediated by the complement terminal pathway.
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