Comorbidities and polypharmacy among HIV-positive patients aged 50 years and over: a case-control study.

Objective: This study was to determine and compare the prevalences of polypharmacy and comorbidities in patients aged 50 years or older with those patients younger than 50 years in a Mexican population.

Results: One hundred and twenty-five patients were enrolled, 60 (48%) were aged 50 years or older. The median CD4+ cell counts were 509 cells/μL (interquartile range [IQR]: 324-730) for the older patients and 384 cells/μL (IQR: 262-562) (P = 0.

Effectiveness of etravirine-based therapy for treatment-experienced HIV-infected patients.

Introduction: Treatment options are limited for HIV-1-infected individuals who have received extensive previous antiretroviral therapy. ETV has shown significant clinical benefits in treatment-experienced HIV-1+ patients with antiretroviral resistance. The aim of this study was to evaluate the effectiveness of ETV plus optimized background regimen in real-life conditions in a cohort of highly HIV-1 antiretroviral-experienced patients.

Effectiveness and risk factors for virological outcome of darunavir-based therapy for treatment-experienced HIV-infected patients.

Objective: We evaluated the effectiveness of darunavir (DRV) treatment plus an optimized background regimen in 120 HIV-1 treatment-experienced patients.

Design: Retrospective cohort, multicenter study.

Methods: Adults >16 years with virological treatment failure starting therapy with a DRV-containing regimen were included.

Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.

Aim: To evaluate the impact of metadoxine (MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis (AH).

Methods: This study was an open-label clinical trial, performed at the "Hospital General de México, Dr. Eduardo Liceaga".

Treatment with metadoxine and its impact on early mortality in patients with severe alcoholic hepatitis.

Background & Aim: Despite treatment with glucocorticoids, mortality remains high in patients with severe alcoholic hepatitis. Oxidative stress and depletion of mitochondrial glutathione are implicated factors in liver injury. The aim of this study was to evaluate the impact of the addition of metadoxine, a drug which possesses a multifactorial mechanism of action, including antioxidant properties, to standard treatment with glucocorticoids in patients with severe alcoholic hepatitis.