Publications by authors named "Javier Conde-Aranda"
Article Synopsis
- - The study investigates the role of the Pyk2 gene in obesity among children and adolescents, noting its previously unclear involvement in energy balance-related diseases.
- - Researchers measured mRNA expression levels of Pyk2 in 130 Caucasian subjects, split into two groups based on Body Mass Index (BMI), and found higher expression levels in those with obesity.
- - The results revealed a positive correlation between Pyk2 expression levels and various obesity-related metrics (like weight, fat mass, and blood pressure), suggesting that Pyk2 may be a potential predictor for developing obesity.
Article Synopsis
- Obesity increases the risk of chronic diseases like osteoarthritis (OA) and rheumatoid arthritis (RA), with adipose tissue functioning as an endocrine organ that releases adipokines, including LCN2, which affect inflammation and immunity.* -
- The study measured LCN2 serum levels in healthy individuals, OA, and RA patients using different treatment methods (conventional treatment and adalimumab), finding elevated LCN2 levels in both OA and RA patients.* -
- The results indicate that LCN2 levels correlate with various inflammatory markers, particularly in RA patients on conventional treatment, suggesting that LCN2 could serve as an additional biomarker for inflammation in rheumatic diseases.*
Article Synopsis
- Legg Calve Perthes disease (LCPD) is a childhood hip disorder caused by reduced blood flow, leading to femoral head deformity if not treated.
- This study investigated four pelvic radiographic parameters to see if they can predict outcomes in LCPD patients, comparing data from healthy vs. affected hips.
- Significant differences were found in three parameters, but only the Acetabular Depth-Width Ratio was predictive of disease outcomes, highlighting the need for more extensive research.
Article Synopsis
- Macrophage metalloelastase (MMP12) is a key enzyme linked to inflammatory diseases like inflammatory bowel disease (IBD), but there's limited knowledge about how its expression is regulated in macrophages.
- This study investigates the connection between MMP12 and IBD, utilizing transcriptional data and RAW 264.7 macrophage cell line experiments to explore the underlying mechanisms of MMP12 regulation.
- Results indicate that MMP12 expression correlates with IBD severity and therapies, and that inhibiting mTORC1 and activating AMPK can enhance MMP12 levels, while blocking MMP12 reduces pro-inflammatory cytokine expression.
Inflammatory bowel disease (IBD) is a global health burden which carries lifelong morbidity affecting all age groups in populations with the disease-specific peak of the age groups ranging between 15 and 35 years, which are of great economic importance for the society. An accelerating incidence of IBD is reported for newly industrialised countries, whereas stabilising incidence but increasing prevalence is typical for countries with a Westernised lifestyle, such as the European area and the USA. Although the aetiology of IBD is largely unknown, the interplay between the genetic, environmental, immunological, and microbial components is decisive for the disease manifestation, course, severity and individual outcomes.
View Article and Find Full Text PDFObjectives: This study investigates the role of retinol binding protein 4 (RBP4) in an articular context. RBP4, a vitamin A transporter, is linked to various metabolic diseases.
Methods: Synovial fluid RBP4 levels were assessed in crystalline arthritis (CA) patients using ELISA.
The present study was conducted to evaluate the protective effect of milk kefir against NSAID-induced gastric ulcers. Male Swiss mice were divided into three groups: control (Vehicle; UHT milk at a dose of 0.3 mL/100 g), proton pump inhibitor (PPI; lansoprazole 30 mg/kg), and 4% milk kefir (Kefir; 0.
View Article and Find Full Text PDFObjective: Class 3 semaphorins are reduced in the synovial tissue of RA patients and these proteins are involved in the pathogenesis of the disease. The aim of this study was to identify the transcription factors involved in the expression of class 3 semaphorins in the synovium of RA patients.
Methods: Protein and mRNA expression in synovial tissue from RA and individuals at risk (IAR) patients, human umbilical vein endothelial cells (HUVEC) and RA fibroblast-like synoviocytes (FLS) was determined by ELISA, immunoblotting and quantitative PCR.
The inflammatory response is an adaptive mechanism that evolved to fight against infections and tissue damage [...
View Article and Find Full Text PDFWnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is a recently identified adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic precursor cells. In osteoarthritis (OA), the most common form of arthritis, chondrocytes exhibit aberrant and increased production of pro-inflammatory mediators and matrix degrading enzymes such as IL-1β and MMP-13. Although recent evidence suggests a role for Wnt signaling in OA physiopathology, little is known about the involvement of WISP-2 in cartilage degradation.
View Article and Find Full Text PDFNigella species have been widely used in traditional medicine. The aim of this study was to evaluate the antiinflammatory and analgesic potentials of Nigella orientalis L. seeds fixed oil (NOO).
View Article and Find Full Text PDFDespite the benefits of current therapeutic options for treating inflammatory bowel disease (IBD), there are still patients who are refractory to these therapies. Moreover, the relapses caused by incomplete intestinal mucosa healing are frequent. Therefore, there is a need for novel pharmacological targets that can improve the existing IBD therapeutic armamentarium.
View Article and Find Full Text PDFInflammation is an essential physiological process that is directed to the protection of the organism against invading pathogens or tissue trauma. Most of the existing knowledge related to inflammation is focused on the factors and mechanisms that drive the induction phase of this process. However, since the recognition that the resolution of the inflammation is an active and tightly regulated process, increasing evidence has shown the relevance of this process for the development of chronic inflammatory diseases, such as inflammatory bowel disease.
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