Publications by authors named "Javier Cavieres-Lepe"
The circadian rhythm of adult emergence (aka eclosion) of the fruit fly Drosophila is a classic behavioural read-out that served in the first characterisation of the key features of circadian clocks and was also used for the identification of the first clock genes. Rhythmic eclosion requires the central clock in the brain, as well as a peripheral clock in the steroidogenic prothoracic gland. Here, we review recent findings on the timing and neuroendocrine coupling mechanisms of the two clocks.
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- Circadian clocks regulate daily behaviors, physiology, and metabolism through central and peripheral clocks, which are synchronized in ways that are not completely known.
- Research focused on the interactions between the central clock and the peripheral clock in the prothoracic gland (PG), which influences the emergence timing of adult flies.
- Key mechanisms include signaling via small neuropeptides and receptor tyrosine kinases, indicating a complex relationship between these clocks that is crucial for understanding circadian rhythms.
In animals, circadian clocks impose a daily rhythmicity to many behaviors and physiological processes. At the molecular level, circadian rhythms are driven by intracellular transcriptional/translational feedback loops (TTFL). Interestingly, emerging evidence indicates that they can also be modulated by multiple signaling pathways.
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