Intrahepatic cholangiocarcinoma surgery: the impact of lymphadenectomy.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignant tumor and its incidence is increasing over the world. At present times, radical liver resection is still the most effective treatment for ICC patients to achieve long term survival. Pathological lymph node metastases (LMN), found in 15% to 45% of the patients, have been recognized as an extremely poor prognostic risk factor, even if curative resection is performed.

Improved waiting-list outcomes in Argentina after the adoption of a model for end-stage liver disease-based liver allocation policy.

In July 2005, Argentina became the first country after the United States to introduce the Model for End-Stage Liver Disease (MELD) for organ allocation. In this study, we investigated waiting-list (WL) outcomes (n = 3272) and post-liver transplantation (LT) survival in 2 consecutive periods of 5 years before and after the implementation of a MELD-based allocation policy. Data were obtained from the database of the national institute for organ allocation in Argentina.

Relevance of residual disease after liver resection for incidental gallbladder cancer.

Objectives: In patients diagnosed with incidental gallbladder cancer (GC), the benefit and optimal extent of further surgery remain unclear. The aims of this study were to analyse outcomes in patients who underwent liver resection following a diagnosis of incidental GC and to determine factors associated with longterm survival.

Methods: A retrospective analysis of patients diagnosed with incidental GC between June 1999 and June 2010 was performed.

Caroli's disease: report of surgical options and long-term outcome of patients treated in Argentina. Multicenter study.

Background: Caroli's disease (CD) management is still controversial.

Aim: The purpose of this study is to report the most frequent clinical features, treatment options, and outcome obtained after surgical management of CD.

Methods: A voluntary survey was conducted.

Evidence of oxidative stress in familial amyloidotic polyneuropathy type 1.

Objective: To evaluate the oxidative state in patients with familial amyloidotic polyneuropathy type 1 (FAP1).

Design: From 3 unrelated families, patients with FAP1 carrying a transthyretin Met-30 mutation were studied. The diagnosis was confirmed by genetic analysis.