Publications by authors named "Javier Botey-Bataller"
Vaccination-induced protection against influenza is greatly diminished and increasingly heterogeneous with age. We investigated longitudinally (up to five time points) a cohort of 234 vaccinated >65-year-old vaccinees with adjuvanted vaccine FluAd across two independent seasons. System-level analyses of multiomics datasets measuring six modalities and serological data revealed that poor responders lacked time-dependent changes in response to vaccination as observed in responders, suggestive of systemic dysregulation in poor responders.
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- * Researchers analyzed cytokine production before and after antibiotic treatment in over 1,000 patients, discovering a negative relationship between antibody production and IL-10 levels, as well as increased IL-1Ra in those with advanced disease.
- * Genome-wide mapping identified 34 cytokine quantitative trait loci (cQTLs), including 31 new ones, linking immune responses to Lyme borreliosis susceptibility and offering insights relevant to other immune-related diseases.
Article Synopsis
- Genetic variation affects how individuals respond to infections, influencing both susceptibility and symptoms of diseases like Lyme borreliosis (LB).
- The study involved genome-wide association studies of 1,138 LB patients and healthy controls, evaluating genetic variants, cytokine responses, and antibody production related to the disease.
- A newly identified genetic variant, rs1061632, was linked to increased susceptibility to LB and associated with immune response alterations, highlighting the genetic factors influencing LB susceptibility and bacterial clearance.
The measles, mumps, and rubella (MMR) vaccine protects against all-cause mortality in children, but the immunological mechanisms mediating these effects are poorly known. We systematically investigated whether MMR can induce long-term functional changes in innate immune cells, a process termed trained immunity, that could at least partially mediate this heterologous protection. In a randomized, placebo-controlled trial, 39 healthy adults received either the MMR vaccine or a placebo.
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