-(4-fluorobenzyl) Arteannuin B induced interaction of ATF-4 and C/EBPβ mediates the transition of breast cancer cells from autophagy to senescence.

ATF-4 is a master regulator of transcription of genes essential for cellular-adaptive function. In response to the quantum and duration of stress, ATF-4 diligently responds to both pro-apoptotic and pro-survival signals converging into either autophagy or apoptosis/senescence. Despite emerging cues implying a relationship between autophagy and senescence, how these two processes are controlled remains unknown.

Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells.

We have recently highlighting the role of spiroisoxazoline arteannuin B derivatives in mediating proinflammatory cytokines like IL-6, TNfα and NO in vitro. In the present study, a series of new β-arylated arteannuin B analogues were synthesized through coupling with arylboroic acids and evaluated for their in vitro cytotoxic activity in a panel of six cancer cell lines. The binding efficiency was verified by docking of the original ligand within the active site of ATPase domain of GRP78 (PDB ID: 3LDL) at a resolution of 2.

Correction: Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles.

Correction for 'Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles' by Javeed Ur Rasool , , 2021, , 10259-10287, DOI: 10.1039/d1ob01709h.

Correction: Triethylamine-methanol mediated selective removal of oxophenylacetyl ester in saccharides.

Correction for 'Triethylamine-methanol mediated selective removal of oxophenylacetyl ester in saccharides' by Javeed Ur Rasool , , 2021, , 338-347, DOI: 10.1039/d0ob02192j.

Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles.

Numerous metal-catalyzed reactions involving internal alkynes and aimed towards synthetically and pharmacologically important alkenes and heterocycles have appeared in the literature. Among these, Cu-catalyzed reactions have a special place, which has prompted the investigation and development of carbon-carbon and carbon-heteroatom bond-forming reactions. These reactions possess wide scope, and during the paths of these reactions, either stable or intermediates are formed the addition of Cu as a core catalyst or synergistic catalyst.

Triethylamine-methanol mediated selective removal of oxophenylacetyl ester in saccharides.

A highly selective, mild, and efficient method for the cleavage of oxophenylacetyl ester protected saccharides was developed using triethylamine in methanol at room temperature. The reagent proved successful against different labile groups like acetal, ketal, and PMB and also generated good yields of the desired saccharides bearing lipid esters. Further, we also observed DBU in methanol as an alternative reagent for the deprotection of acetyl, benzoyl, and oxophenylacetyl ester groups.