Frequency and clinicopathological correlations of histopathological variants of idiopathic focal segmental glomerulosclerosis in nephrotic adolescents.

Objective: To determine the frequency and clinicopathological correlations of focal segmental glomerulosclerosis variants in adolescents with idiopathic nephrotic syndrome.

Methods: All consecutive adolescents (12 to 18 years) who presented with idiopathic nephrotic syndrome in the period, January 2009 to December 2012, and in whom the histological diagnosis of focal segmental glomerulosclerosis was made on renal biopsies, were included in this prospective study. Their clinical, laboratory and histopathological features at the time of presentation or biopsy were noted from the case files and the biopsy reports.

Acute renal failure in a young female with vaginal bleeding with partial recovery.

Implication for health policy/practice/research/medical education: Glomerular collapse is one of the morphological patterns of response of kidney parenchyma to a variety of noxious agents. As such, it is commonly observed on renal biopsies showing a variety of diseases. It is important to report this lesion in the context of underlying major pathology so as not to confuse it with idiopathic collapsing glomerulopathy.

Oxidative DNA damage as a potential early biomarker of Helicobacter pylori associated carcinogenesis.

Helicobacter pylori infection is an established risk factor for gastritis, gastric ulcer, peptic ulcer and gastric cancer. CagA +ve H. pylori has been associated with oxidative DNA damage of gastric mucosa but their combined role in the development of gastric cancer is still unknown.

Frequency and clinicopathological characteristics of variants of primary focal segmental glomerulosclerosis in adults presenting with nephrotic syndrome.

Background: There is no information on the frequency and clinicopathological presentation of the variants of primary focal segmental glomerulosclerosis (FSGS) in adults presenting with idiopathic nephrotic syndrome (INS) in Pakistan.

Objectives: The aim of this study was to determine the frequencies of different histologic variants of primary FSGS with INS at our center and to compare our findings with those published in literature.

Patients And Methods: All consecutive adults (≥18 years) with INS, and diagnosis of FSGS on renal biopsies, were included.

Reticular type parotid myoepithelial carcinoma: an intriguing variant and mimicker.

Myoepithelial carcinoma, the malignant counterpart of benign myoepithelioma, is one of the rarest salivary gland neoplasms. It is composed almost exclusively of tumour cells with myoepithelial differentiation, characterized by infiltrative growth and potential for metastasis. We herein, report a case of myoepithelial carcinoma in a 50 years old male with reticular morphology.

IgM nephropathy revisited.

IgM nephropathy (IgMN) is an idiopathic immune complex-mediated glomerulopathy that was first described as a distinct disease in a nephropathology literature in 1978. Here, a historical review and the current status of IgMN in the light of world literature and the current experience will be presented. The Pubmed (www.

The prevalence and clinicopathological profile of IgM nephropathy in children with steroid-resistant nephrotic syndrome at a single centre in Pakistan.

Background: There is little information on the clinicopathological characteristics of IgM nephropathy (IgMN) in paediatric steroid-resistant nephrotic syndrome (SRNS) and its response to calcineurin inhibitors (CNI).

Material And Methods: This study was conducted at Sindh Institute of Urology and Transplantation, from January 2009 to August 2011. All SRNS children who received renal biopsies were included.

The spectrum of histopathological lesions in children presenting with steroid-resistant nephrotic syndrome at a single center in Pakistan.

Steroid-resistant nephrotic syndrome (SRNS) is a common problem in pediatric nephrology practice. There is currently little information in the literature on the spectrum of histopathologic lesions in children presenting with SRNS in Pakistan. This study was designed to determine the histopathologic lesions in children presenting with SRNS at our center.

A clinicopathologic study of primary focal segmental glomerulosclerosis in children.

There is very little information in the literature on the treatment and prognosis of primary focal segmental glomerulosclerosis (FSGS) among children in Pakistan. This is a review of 94 children (≤16 years) with a diagnosis of primary FSGS who presented to the Sindh Institute of Urology and Transplantation between 1995 and 2008. The clinical records and original renal biopsy reports were reviewed to determine demographic, clinical, laboratory and pathologic features.

Histopathology of surgically treated renal tumours in young adults: a developing country perspective.

Background: There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan.

Materials And Methods: We retrospectively analysed 133 young adults (age: 16 to ≤40 years) who underwent nephrectomy for suspected renal cancer from 1994 till July 2010. The demographical and pathological parameters were determined from original surgical biopsy reports and case files, and analysed.

Extraskeletal osteosarcoma.

A 50 years old male presented with ulcer and swelling in left leg for 2 years. X-ray showed soft tissue sarcoma and excision was done. A diagnosis of extraskeletal osteosarcoma was made.

Pathology of idiopathic nephrotic syndrome in children: are the adolescents different from young children?

Background: There is no specific data on the pathological lesions underlying idiopathic nephrotic syndrome (INS) in adolescents in Pakistan. Moreover, it is not known whether the pathological lesions in adolescents differ significantly from young children with INS in our setup. Materials and methods.

Histopathological characteristics of adult renal tumours: a preliminary report.

Objective: To determine the relative frequencies of different renal tumours in adults and to analyze the histopathologic characteristics of renal cell carcinoma and its variants in the population studied.

Methods: The study was carried out at Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT) from April 2004 to October 2004. All consecutive adult patients with renal tumours managed surgically with tumour nephrectomies, were included.

Clinicopathologic characteristics and steroid response of IgM nephropathy in children presenting with idiopathic nephrotic syndrome.

There is no detailed information on clinical and immunopathologic features of immunoglobulin M nephropathy (IgMN) in children with idiopathic nephrotic syndrome (INS) in Pakistan. We reviewed our native renal biopsies over 15 years (July 1995-July 2010) and identified 135 cases of IgMN in nephrotic children (≤17 years). Their demographic, clinical and immunopathologic data were retrieved from biopsy reports and case notes.

Pattern of renal diseases observed in native renal biopsies in adults in a single centre in Pakistan.

Aim: In the absence of a national renal biopsy registry, there is a paucity of information on the pattern of renal disease observed in native renal biopsies in adults in Pakistan.

Methods: A retrospective review of native renal biopsies performed in adult patients was undertaken at the Sindh Institute of Urology and Transplantation (SIUT) during the period from July 1995 to December 2008. Renal biopsies were studied by light, immunofluorescence and electron microscopy.

Collapsing FSGS: a clinicopathologic study of 10 cases from Pakistan.

Background: Idiopathic collapsing focal segmental glomerulosclerosis (FSGS), a rare variant of FSGS, is of interest because of its increasing incidence, frequent association with black race, HIV-1 infection, and intravenous (IV) drug abuse. This lesion has not been reported from Pakistan until now.

Methods: We reviewed our 14-year native renal biopsies record and identified 10 cases of this entity (July 1995-July 2009).

Pattern of pediatric renal disease observed in native renal biopsies in Pakistan.

Introduction: In the absence of a national pediatric renal biopsy registry, there is a paucity of information on the pattern of childhood renal disease observed in Pakistan. A few studies previously reported are based on light microscopic study of renal biopsies only. This is the first study from this country which is based on light, immunofluorescence and electron microscopic study of native renal biopsies.