Novel ophthalmic hyaluronic acid-hydrogel with curcumin nanoparticles for enhanced healing of ulcerative keratitis in rabbit model.

Corneal ulcers, whether melting or indolent, are common in humans and companion animals. Treatment involves local administration of antibiotic eye drops and corneal healing drugs. Compared to traditional treatments for ulcerative keratitis, herbal medicines offer unique advantages, such as potent anti-inflammatory effects and inhibition of proinflammatory cytokines.

Fabrication of chitosan-polyethylene glycol nanocomposite films containing ZIF-8 nanoparticles for application as wound dressing materials.

Biocompatible nanocomposite films based on chitosan (CS) and polyethylene glycol (PEG) polymers containing cephalexin (CFX) antibiotic drug and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) were designed and fabricated to develop wound dressing materials capable of controlled drug release. Swelling experiment was performed in three acidic, neutral, and alkaline solutions. The tensile strength test reflected that upon increasing the NPs loading within the films, the tensile strength was enhanced but the elongation at break was diminished.

Development and characterization of a novel conductive polyaniline-g-polystyrene/FeO nanocomposite for the treatment of cancer.

The goal of this study is to synthesize, characterize and investigate some physicochemical properties of conductive polyaniline-g-polystyrene/FeO (FeO/PSt-g-PANi) nanocomposites. For this purpose, initially, FeO nanoparticles were synthesized by a co-precipitation method. Then, the desired nanocomposite was synthesized in two steps.

Porous MnFeO@SiO magnetic glycopolymer: A multivalent nanostructure for efficient removal of bacteria from aqueous solution.

The focuses of this research is to prepare an efficient magnetic glycopolymer for bacteria removal from aqueous solution. To perform this idea; porous MnFeO@SiO was functionalized with glucose and or maltose as an anchors to adhere onto bacteria cell surface. Aminopropyltriethoxysilane was employed to link the saccharides on magnetic nanoparticle surface.

Glucose reinforced FeO@cellulose mediated amino acid: Reusable magnetic glyconanoparticles with enhanced bacteria capture efficiency.

In this study glucose reinforced FeO@cellulose glyconanoparticles (MGN) were prepared using epichlorohydrin and amino acid (lysine and arginine) as a linker. Bacillus capturing capability of amino acid modified FeO@cellulose was compared to the glucose reinforced system. Results showed enhanced bacterial capturing of MGN relative to amino acid modified particles.

Application of nanostructured drug delivery systems in immunotherapy of cancer: a review.

The cancer immunotherapy method uses the specificity of the immune system to provide a more effective than more conventional treatments, such as chemotherapy and radiotherapy. Immunotherapy has two main strategies (passive or active) to organize the immune system. Passive strategies use advantage of tumor-hyperpermeable cells, which have enhanced permeability and retention effects.