Substitution of Glutamic Acid at Position 71 of DRβ1*04:01 Induces Collagen-Specific Tolerance Without Inducing Alloreactivity.

Objective: The DRB1 locus is strongly associated with both susceptibility and resistance to rheumatoid arthritis (RA). DRB1 alleles encoding the VKA or VRA epitope in positions 11, 71 and 74 confer the highest risk of developing RA, while the allele encoding VEA is protective. We therefore investigated the feasibility of creating antigen-specific tolerance without inducing alloreactivity by replacing lysine with glutamic acid at position 71 in DRβ1*04:01.

Efficacy of 4% articaine 2% lidocaine in mandibular and maxillary block and infiltration anaesthesia in patients with irreversible pulpitis: a systematic review and meta-analysis.

Objective: The goal of this systematic review and meta-analysis is to determine the performance of 4% Articaine 2% Lidocaine for mandibular and maxillary block and infiltration anaesthesia in patients with irreversible pulpitis (IP).

Methods: PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Google Scholar, and Open Gray were used to conduct a thorough literature search. A manual search of the reference lists of the publications found was also carried out.

Occlusal plane determination using custom made broadrick occlusal plane analyser: a case control study.

Proper occlusal plane is an essential consideration when multiple long span posterior restorations are designed. The determination of the occlusal plane can have a profound effect on the short and long term success of a restorative case. Purpose of Study.