Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial/anticancer agents: unusual bio-activity against methicillin resistant , , and and human bone cancer cell line.

The basic aim of this study pertains to the synthesis of silver nitrate complexes and the study of their antimicrobial and anticancer bio-activity. A series of new silver(i) derivatives of -substituted-imidazolidine-2-thiones (L-NR, R = Et, Pr , Bu , Ph), purine-6-thione (purSH), 2-thiouracil (tucH), pyrimidine-2-thione (pymSH) and pyridine-2-thione (pySH) of composition [Ag(S-L-NR)(PPh)(ONO)] {R = Et (1), Pr (2), Bu (3), Ph (4)}, [Ag(N,S-purSH)(μ-dppm)](NO)·2HO (5) (dppm = PhP-CH-PPh), [Ag(L)(PPh)](NO) {L = N,S-purSH (6); S-tucH (7)}, [Ag(N,S-pymS)(PPh)](CHOH) (8), and [Ag(N,S-pyS)(PPh)] (9) have been synthesized and structurally characterized. These new and some previously reported complexes {[Ag(L-NH)(PPh)](NO) (10), [Ag(L-NMe)(PPh)](NO) (11), and [Ag(S-bzimSH)(PPh)](OAc) (12), L-NH = 1,3-imidazolidine-2-thione; L-NMe = 1-methyl-3-imidazolidine-2-thione and bzimSH = benzimidazoline-2-thione)} have shown moderate to high anti-microbial activity against Gram positive bacteria, namely methicillin resistant (MRSA) and (MTCC 740), and Gram negative bacteria, namely (MTCC 435), (MTCC 439), (MTCC 1457) and a yeast (MTCC 22).

Correction: Variable coordination and C-S bond cleavage activity of N-substituted imidazolidine-2-thiones towards copper: synthesis, spectroscopy, structures, ESI-mass and antimicrobial studies.

Correction for 'Variable coordination and C-S bond cleavage activity of N-substituted imidazolidine-2-thiones towards copper: synthesis, spectroscopy, structures, ESI-mass and antimicrobial studies' by Jaspreet K. Aulakh, et al., Dalton Trans.

Synthesis, structures, and ESI-mass studies of silver(I) derivatives of imidazolidine-2-thiones: Antimicrobial potential and biosafety evaluation.

The basic objective of this investigation is to explore potential metallo-organic antimicrobial agents based on silver-heterocyclic-2-thiones. In this respect, a series of silver(I) halide complexes with imidazolidine-2-thiones (L-NR, R=H, Me, Et, Pr, Bu, Ph), namely, mononuclear [AgX(L-NR)(PPh)] (X, R: Cl, Bu, 1; Br, Ph, 7); [AgX(L-NR)] (Br, Bu, 5; Br, Pr, 8) and halogen bridged dinuclear [Ag(μ-X)(L-NR)(PPh)] (Cl, Bu, 2; Cl, Ph, 3; Cl, Pr, 4; Br, Ph, 6) have been synthesized and characterized using modern techniques. The thio-ligands are terminally S-bonded in all the complexes.

Variable coordination and C-S bond cleavage activity of N-substituted imidazolidine-2-thiones towards copper: synthesis, spectroscopy, structures, ESI-mass and antimicrobial studies.

An equimolar reaction of copper(i) iodide with N-ethyl-imidazolidine-2-thione (l-Et) in acetonitrile formed black prismatic crystals over a period of three weeks. The X-ray structure determination of black crystals revealed that the thio-ligand l-Et has transformed into a new thio-ligand, 1-ethyl-3-(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)imidazolidine-2-thione (l-NEt), through C-S rupture/C-N bond formation which was coordinated in the unusual 2D polymer, {(Cu(κ-N,S-l-NEt))·(CuI)·(CuI)}1. An ESR spectrum supported the presence of divalent Cu in the polymer.

Progressive Resistance Exercise Training in CKD: A Feasibility Study.

Background: Skeletal muscle wasting in chronic kidney disease (CKD) is associated with morbidity and mortality. Resistance exercise results in muscle hypertrophy in the healthy population, but is underinvestigated in CKD. We aimed to determine the feasibility of delivering a supervised progressive resistance exercise program in CKD, with secondary aims to investigate effects on muscle size, strength, and physical functioning.