Publications by authors named "Jasper Wouda"
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts.
View Article and Find Full Text PDFImportance: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63,000 participants (including MDD cases).
View Article and Find Full Text PDFArticle Synopsis
- Mega-analytic studies in behavior genetics often face challenges in harmonizing different measures of personality traits, necessary for effective analysis.
- This research, conducted by the Genetics of Personality Consortium, utilized Item-Response Theory (IRT) to align data from over 160,000 individuals across 23 cohorts assessing Neuroticism and Extraversion through nine different inventories.
- The findings revealed that IRT successfully standardized measurements, confirmed heritability of these traits, and suggested that genetic influences show differences based on sex, highlighting the method's potential for enhancing statistical power in similar studies.