Molecular Iodine-Mediated β-Glycosylation of Thiomannosides with 1,6-Anhydrosugars.

β-Mannosides play a crucial role in cellular processes and immune responses, and their synthesis remains one of the most challenging tasks in carbohydrate chemistry. Glycosyl donors, such as thiomannosides, are stable and compatible with a range of protection and deprotection conditions. In this study, we demonstrate that molecular iodine efficiently induces the activation and coupling of thiomannosides with various 1,6-anhydrosugars as acceptors.