Publications by authors named "Jason Y Shen"
The grid-like activity pattern of cells in the mammalian entorhinal cortex provides an internal reference frame for allocentric self-localization. The same neurons maintain robust phase couplings with local field oscillations. We found that neurons of the human entorhinal cortex display consistent spatial and temporal phase locking between spikes and slow gamma band local field potentials (LFPs) during virtual navigation.
View Article and Find Full Text PDFContext-dependent spatially periodic activity in the human entorhinal cortex.
Proc Natl Acad Sci U S A
April 2017
Article Synopsis
- Grid cells in the entorhinal cortex provide a spatial coordinate system that helps individuals understand their location and remember it, featuring unique properties like 60° symmetry and consistent scaling across different environments.
- Research on humans with entorhinal cortical implants performing navigation tasks has revealed that human grid cells can adapt their activity based on the size and shape of their environment and visual cues.
- The study indicates that human entorhinal cortical neurons are more flexible than those in rodents, displaying an ability to adjust their scaling and context sensitivity when representing space.
Successful use of topiramate in a patient with severe postherpetic neuralgia.
Ann Pharmacother
January 2009
Objective: To describe the case of a patient with postherpetic neuralgia (PHN) who had a marked response to topiramate despite failure of several previous therapies.
Case Summary: A 79-year-old white male with multiple medical comorbidities developed severe trigeminal territory PHN requiring treatment with opiates to maintain adequate pain relief. Topiramate was initiated after the patient failed treatment with 4 other antiepileptic medications due to various adverse events.