Publications by authors named "Jason Valerio"
Introduction: Sleep disturbances are common in Alzheimer's disease (AD), with estimates of prevalence as high as 65%. Recent work suggests that specific sleep stages, such as slow-wave sleep (SWS) and rapid eye movement (REM), may directly impact AD pathophysiology. A major limitation to sleep staging is the requirement for clinical polysomnography (PSG), which is often not well tolerated in patients with dementia.
View Article and Find Full Text PDFSleep disturbances are common in Alzheimer's disease and other neurodegenerative disorders, and together represent a potential therapeutic target for disease modification. A major barrier for studying sleep in patients with dementia is the requirement for overnight polysomnography (PSG) to achieve formal sleep staging. This is not only costly, but also spending a night in a hospital setting is not always advisable in this patient group.
View Article and Find Full Text PDFArticle Synopsis
- Some people with a genetic change called LRRK2 have different brain inflammation and activity compared to those with common Parkinson's disease.
- Researchers studied patients from several countries to see how these genetic changes affect brain activity related to a chemical called acetylcholine.
- They found that LRRK2 carriers, even if they didn't have Parkinson's yet, showed signs of changes in brain activity that were different from healthy people.
Article Synopsis
- Two patients experienced swelling around their eyes (periorbital edema) after starting positive airway pressure (PAP) therapy using a full face mask.
- The swelling was worse in the morning and decreased throughout the day, possibly due to the mask's pressure affecting fluid drainage.
- When the patients switched to a nasal pillow interface, their eye swelling improved significantly.