Cerebellar abscess in a cynomolgus macaque (Macaca fascicularis).

Background: A cynomolgus macaque (Macaca fascicularis) presented with decreased appetite, lethargy, ataxia, disorientation and visual impairment. It was used in a hepatitis B (HBV) study involving injections of HBV plasmid construct (450 microg) and aflatoxin B1 (25 microg/kg) in an effort to develop a model of liver cirrhosis and hepatocellular carcinoma.

Methods: The case work-up included physical examination, including assessment of hydration, thoracic and abdominal radiographs and abdominal ultrasound.