Does sedation type affect colonoscopy perforation rates?

Background: Sedation with propofol is gaining popularity. It is unclear whether sedation with propofol is associated with colonoscopic perforation.

Objective: The purpose of this study was to compare perforation rates during colonoscopy using sedation with or without propofol.

Evaluating the age distribution of patients with colorectal cancer: are the United States Preventative Services Task Force guidelines for colorectal cancer screening appropriate?

Purpose: Evaluate the appropriateness of the 2008 United States Preventative Services Task Force screening recommendations for colorectal cancer.

Methods: Ages at diagnosis data were collected on patients with colorectal cancer from the William Beaumont Tumor Registry. The database identified 6,925 patients treated for colorectal cancer between January 1973 and December 2007.

Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot.

Juvenile polyposis (JP) is an autosomal dominant syndrome in which affected patients develop upper- and/or lower-gastrointestinal (GI) polyps. A subset of families with JP have germline mutations in the SMAD4 (MADH4) gene and are at increased risk of GI cancers. To date, six families with JP have been described as having the same SMAD4 deletion (1244-1247delAGAC).