Publications by authors named "Jason R Bock"
Introduction: Word-list recall tests are routinely used for cognitive assessment, and process scoring may improve their accuracy. We examined whether Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) derived, process-based digital cognitive biomarkers (DCBs) at baseline predicted Clinical Dementia Rating (CDR) longitudinally and compared them to standard metrics.
Methods: Analyses were performed with Alzheimer's Disease Neuroimaging Initiative (ADNI) data from 330 participants (mean age = 71.
Cognitive assessment with wordlist memory tests is a cost-effective and non-invasive method of identifying cognitive changes due to Alzheimer's disease and measuring clinical outcomes. However, with a rising need for more precise and granular measures of cognitive changes, especially in earlier or preclinical stages of Alzheimer's disease, traditional scoring methods have failed to provide adequate accuracy and information. Well-validated and widely adopted wordlist memory tests vary in many ways, including list length, number of learning trials, order of word presentation across trials, and inclusion of semantic categories, and these differences meaningfully impact cognition.
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- A study measured antibody prevalence for COVID-19 among healthcare workers (HCWs) and community first responders to better understand their susceptibility and support improved health policies.
- Blood samples were collected from 3,458 HCWs and 226 first responders at two-time points, revealing higher antibody rates in first responders than HCWs (5.31% vs. 0.93%).
- The results suggest lower antibody prevalence among HCWs than seen in other studies, pointing to effective workplace safety measures, yet highlighting the need for further research on this discrepancy.
Article Synopsis
- Serological surveys have shown varying prevalence rates of COVID-19 antibodies, particularly among healthcare workers, necessitating further research on risks and transmission in various healthcare environments.
- A study conducted in Orange County, California, in May-June 2020 tested 2,992 healthcare workers for SARS-CoV-2 IgG antibodies, with an observed prevalence of 1.06%, slightly adjusted to 1.13% after considering test accuracy.
- Significant differences in antibody prevalence were noted related to age, race, and specific COVID-19 symptoms, but not occupational roles, with low local community prevalence and effective safety measures likely contributing to the low observed rates among healthcare workers.