Publications by authors named "Jason Morrissette"
Objectives: This study aims to compare veterans and non-veterans undergoing transcatheter aortic valve replacement (TAVR) using data from the Society for Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy (STS/ACC TVT) registry.
Methods: Patients undergoing TAVR at George Washington University (GWU) and veterans treated at Washington DC Veterans Affairs Medical Center (VAMC) who underwent TAVR at GWU from 2014-2020 were included. All patients were reported in the TVT registry.
The purpose of this investigation was to characterize the CMR and clinical parameters that correlate to prosthetic valve size (PVS) determined at SAVR and develop a multi-parametric model to predict PVS. Sixty-two subjects were included. Linear/area measurements of the aortic annulus were performed on cine CMR images in systole/diastole on long/short axis (SAX) views.
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- - The research aimed to investigate the existence of a "morbidity tipping point," a point in adulthood that marks a shift from relative health to increasing health issues, and a similar tipping point for healthcare costs.
- - The study analyzed data from over 55,000 adults collected between 2006 and 2009, finding that morbidity starts to rise exponentially around age 45.5, while healthcare costs begin to increase significantly around age 39.5.
- - The results confirmed that both morbidity and costs increase rapidly after their respective tipping points, indicating that significant health deterioration and escalating costs may begin earlier in life than previously thought.
Objective: In valvular heart disease, elevated left atrial and pulmonary pressures contribute to right ventricular strain and, ultimately, right ventricle failure. Elevated pulmonary artery (PAP) and left ventricular end diastolic pressures are used as markers of right ventricle dysfunction and correlate with poor outcomes. Using cardiac magnetic resonance imaging (CMR), it is possible to directly quantify both left and right ventricular ejection function (LVEF and RVEF), and here, we compare CMR with traditional markers as outcome predictors.
View Article and Find Full Text PDFWhen interactions are identified in analysis of covariance models it becomes important to identify values of the covariates for which there are significant differences or, more generally, significant contrasts among the group mean responses. Inferential procedures that incorporate a priori order restrictions among the group mean responses would be expected to be superior to those that ignore this information. In this paper we focus on analysis of covariance models with pre-specified order restrictions on the mean response across the levels of a grouping variable when the grouping variable may interact with model covariates.
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- Pulmonary Fibrosis (PF) is a serious disease characterized by lung scarring, often caused by treatments like chemotherapy, radiation, or systemic diseases such as rheumatoid arthritis.
- CDDO-Me, a new triterpenoid compound, has shown promising anti-fibrotic and anti-inflammatory effects in laboratory studies, leading researchers to test it in a mouse model of lung injury.
- Results from these studies indicated that CDDO-Me significantly reduced inflammation and fibrosis markers, improved lung function, and shows potential as a treatment for patients at risk of lung damage from cancer therapies and autoimmune disorders.