High Systemic Disease Risk and Therapeutic Delays in Plaque Psoriasis: A Retrospective Analysis of Apremilast Use in the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR).

Introduction: We describe comorbidities and cardiovascular diseases (CVD) risk in patients with psoriasis prescribed apremilast in UK clinical practice. Such real-world data are currently sparse.

Methods: This observational, retrospective analysis of British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR) included adults with plaque psoriasis first prescribed apremilast between October 2015 and March 2021.

An integrated framework for the optimisation of sport and athlete development: a practitioner approach.

This paper introduces a new sport and athlete development framework that has been generated by multidisciplinary sport practitioners. By combining current theoretical research perspectives with extensive empirical observations from one of the world's leading sport agencies, the proposed FTEM (Foundations, Talent, Elite, Mastery) framework offers broad utility to researchers and sporting stakeholders alike. FTEM is unique in comparison with alternative models and frameworks, because it: integrates general and specialised phases of development for participants within the active lifestyle, sport participation and sport excellence pathways; typically doubles the number of developmental phases (n = 10) in order to better understand athlete transition; avoids chronological and training prescriptions; more optimally establishes a continuum between participation and elite; and allows full inclusion of many developmental support drivers at the sport and system levels.