Publications by authors named "Jason Mo"
Background And Aims: The impact of the COVID-19 pandemic on patients with inflammatory bowel disease [IBD] is largely unknown. We characterised the impact of COVID-19 on IBD care by conducting an analysis of US health care claims data.
Methods: We obtained de-identified, open-source, health insurance claims data, from January 2019 to December 2020, from the Symphony Health Integrated Dataverse for US adults with IBD, and measured the rates per 1000 patients of five outcomes: colonoscopies; new biologic or small molecule treatment initiations or treatment switches; new biologic or small molecule treatment initiations or treatment switches in patients who had a colonoscopy within the previous 60 days; IBD-related surgeries; and telehealth consultations.
Article Synopsis
- PARP14 is a protein overexpressed in various tumors, affecting macrophage behavior and suppressing immune responses by altering key signaling molecules like IFN-γ and IL-4.
- It has a complex structure with different functional domains that allow it to interact with ADP-ribose and RNA, but the specific roles of some domains in immunity are still unclear.
- Researchers created a new small molecule that inhibits PARP14 by binding to its NAD site and tagging it for degradation, potentially offering insights into its involvement in cancer and inflammation.