Publications by authors named "Jason M Schallheim"
Article Synopsis
- Prostate cancer often spreads to the bone, causing severe health issues, and the protein MTA1 is found in high levels in metastatic tumors, though its specific function is still unclear.
- Research revealed that silencing MTA1 reduces tumor growth and bone metastasis formation in various cancer models by affecting the cells' ability to invade and migrate.
- MTA1 affects the expression of cathepsin B (CTSB), a key player in bone metastasis, while increasing E-cadherin levels, suggesting that targeting the MTA1/CTSB pathway could help prevent bone metastasis in prostate cancer.
Lung cancer histologic diagnosis is clinically relevant because there are histology-specific treatment indications and contraindications. Histologic diagnosis can be challenging owing to tumor characteristics, and it has been shown to have less-than-ideal agreement among pathologists reviewing the same specimens. Microarray profiling studies using frozen specimens have shown that histologies exhibit different gene expression trends; however, frozen specimens are not amenable to routine clinical application.
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