Publications by Jason M Nogieira

Publications by authors named "Jason M Nogieira"

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Application of Thiol-yne/Thiol-ene Reactions for Peptide and Protein Macrocyclizations.

Yuanxiang Wang Benjamin J Bruno Sean Cornillie Jason M Nogieira Diao Chen

Chemistry

May 2017

The application of thiol-yne/thiol-ene reactions to synthesize mono- and bicyclic-stapled peptides and proteins is reported. First, a thiol-ene-based peptide-stapling method in aqueous conditions was developed. This method enabled the efficient stapling of recombinantly expressed coil-coiled proteins.

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