Publications by authors named "Jason Jinyue Liao"
Article Synopsis
- In myelodysplastic syndrome (MDS), resistance to hypomethylating agents (HMA) indicates a poor prognosis, emphasizing the need to comprehend the mechanisms behind HMA-resistance.
- This study analyzed P39 and Kasumi-1 cell lines, including their resistant sublines, through transcriptomic and methylomic methods, finding notable downregulation linked to DNA hypermethylation in resistant cells.
- Long-read sequencing revealed RNA hypomethylation in azacitidine-resistant P39 cells, leading to alternative splicing and a truncated transcript, which was also more prevalent in patients who resisted HMA treatment.
