Perception of pneumocystis jirovecii pneumonia (PJP) prophylaxis in glioma patients receiving concurrent temozolomide and radiation- a patient and physician survey.

Purpose: Pneumocystis jirovecii pneumonia (PJP) prophylaxis is required by provincial and national drug monographs during glioma treatment using temozolomide (TMZ) concurrently with radiation (TMZ-RT). However, real-world data suggest the potential benefits of PJP prophylaxis may not outweigh its potential harms in this population.

Methods: We conducted a single-center patient survey and a national physician survey to explore the role of PJP prophylaxis amongst glioma patients undergoing TMZ-RT.

Poly[bis-[μ-1,3-bis-(pyridin-4-yl)urea-κ:]bis-(μ-5-methyl-isophthalato-κ:)dizinc(II)], a parallel inter-penetrated slab-like coordination polymer with {3.68}{36.78} 4,4-connected binodal topology.

In the title compound, [Zn(CHO)(CHNO)], diperiodic coordination polymer slabs with {3.68}{36.78} 4,4-connected binodal topology are held into a parallel inter-penetrated triperiodic crystal structure by means of N-H⋯O hydrogen-bonding patterns.

Poly[[μ-1,4-bis-(pyridin-4-ylmeth-yl)piperazine]bis-[μ-4-(2-carboxyl-atoeth-yl)benzoato]dicopper(II)].

In the title coordination polymer, [Cu(CHO)(CHN)], the Cu atoms in {NO} square-pyramidal coordination environments are conjoined into diperiodic coordination polymer slabs by the full span of the bridging 1,4-bis-(pyridin-4-ylmeth-yl)piperazine (bpmp) and 4-(carboxyl-eth-yl)benzoate (ceb) ligands. The slab motifs are expanded into the full crystal structure by means of longer-range C-H⋯O attractive inter-actions.

Poly[[aqua-[μ-1,3-bis-(pyridin-4-yl)urea-κ:]bis-(μ-5--butyl-isophthalato-κ::)dizinc(II)] trihydrate], a double-strand coordination polymer.

In the title compound, {[Zn(CHO)(CHNO)(HO)]·3HO}, monoperiodic coordination polymer double strands are held into the triperiodic crystal structure by means of N-H⋯O hydrogen-bonding patterns between the amide groups of the 1,3-di(pyridin-4-yl)urea ligands and unligated O atoms belonging to 5--butyl-isophthalate ligands. One of the Zn atoms displays a tetra-hedral coordination environment, while the other Zn atom adopts a five-coordinate geometry inter-mediate between square pyramidal and trigonal bipyramidal. Additionally, O-H⋯O hydrogen-bonding patterns involving the water mol-ecules of crystallization serve as a structure-stabilizing element by aggregating the double-strand motifs.

Temozolomide Chronotherapy in Glioma: A Systematic Review.

Outcomes for patients with high-grade glioma remain poor. Temozolomide (TMZ) is the only drug approved for first-line treatment of glioblastoma multiforme, the most aggressive form of glioma. Chronotherapy highlights the potential benefit of timed TMZ administration.

Effect of inpatient antibiotic treatment among older adults with delirium found with a positive urinalysis: a health record review.

Background: Among older adults with delirium and positive urinalysis, antibiotic treatment for urinary tract infection is common practice, but unsupported by literature or guidelines. We sought to: i) determine the rate of antibiotic treatment and the proportion of asymptomatic patients (other than delirium) in this patient population, and ii) examine the effect of antibiotic treatment on delirium resolution and adverse outcomes.

Methods: A health record review was conducted at a tertiary academic centre from January to December 2020.

Latitudinal differences on the global epidemiology of infantile spasms: systematic review and meta-analysis.

Background: Infantile spasms represent the catastrophic, age-specific seizure type associated with acute and long-term neurological morbidity. However, due to rarity and heterogenous determination, there is persistent uncertainty of its pathophysiological and epidemiological characteristics. The purpose of the current study was to address a historically suspected latitudinal basis of infantile spasms incidence, and to interrogate a geographical basis of epidemiology, including the roles of latitude and other environmental factors, using meta-analytic and -regression methods.

Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase Expression.

Estrogens dramatically dilate numerous vascular beds with the greatest response in the uterus. Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). We hypothesized that estrogen replacement therapy (ERT) selectively stimulates H2S biosynthesis in uterine artery (UA) and other systemic arteries.

The effect of the number and size of animated conspecific images on shoaling responses of zebrafish.

The zebrafish is increasingly utilized in biomedical and psychopharmacological research aimed at modeling human brain disorders. Abnormal social behavior represents the core symptom of several neuropsychiatric and neurodevelopmental disorders. The zebrafish is a highly social species and has been proposed for modeling such disorders.

Short-term memory in zebrafish (Danio rerio).

Learning and memory represent perhaps the most complex behavioral phenomena. Although their underlying mechanisms have been extensively analyzed, only a fraction of the potential molecular components have been identified. The zebrafish has been proposed as a screening tool with which mechanisms of complex brain functions may be systematically uncovered.