Publications by authors named "Jason J Biemond"
Article Synopsis
- - The study focused on understanding community-acquired sepsis in lower middle-income countries like India, highlighting the influence of tropical infections and microbiology on the condition's causes and outcomes.
- - Conducted from December 2018 to September 2022, the research involved over 1000 patients admitted to an ICU, revealing a median age of 55 years and significant mortality rates, particularly among those from rural areas and working in primary sectors.
- - Findings indicated that sepsis cases often stemmed from tropical and viral infections, with notable resistance to common antibiotics, underscoring the need for targeted public health strategies in India and contributing to global sepsis research.
Background: The immunological determinants of delayed viral clearance and intrahost viral evolution that drive the development of new pathogenic virus strains in immunocompromised individuals are unknown. Therefore, we longitudinally studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in relation to viral clearance and evolution in immunocompromised individuals.
Methods: Among Omicron-infected immunocompromised individuals, we determined SARS-CoV-2-specific T- and B-cell responses, anti-spike immunoglobulin G (IgG) and IgG3 titers, neutralization titers, and monoclonal antibody (mAb) resistance-associated mutations.
Importance: Pre-exposure prophylaxis with neutralizing SARS-CoV-2 monoclonal antibodies (mAbs PrEP) prevents infection and reduces hospitalizations and the duration thereof for COVID-19 and death among high-risk individuals. However, reduced effectiveness due to a changing SARS-CoV-2 viral landscape and high drug prices remain substantial implementation barriers.
Objective: To assess the cost-effectiveness of mAbs PrEP as COVID-19 PrEP.
Article Synopsis
- The text talks about how scientists are trying to use tiny living things called microbes to help treat people with sepsis, a serious illness.
- Though some recent studies didn’t show good results with using probiotics, which are good microbes, researchers believe it’s important to keep trying.
- They think that finding new kinds of probiotics and understanding the balance of microbes in our bodies can help improve chances of survival for patients with sepsis in the future.
This study investigates whether resistance-associated mutations develop after treatment with sotrovimab in high-risk patients infected with the SARS-CoV-2 Omicron variant.
View Article and Find Full Text PDFPurpose Of Review: Melioidosis, caused by the soil-dwelling bacterium Burkholderia pseudomallei, is a tropical infection associated with high morbidity and mortality. This review summarizes current insights into melioidosis' endemicity, focusing on epidemiological transitions, zoonosis, and climate change.
Recent Findings: Estimates of the global burden of melioidosis affirm the significance of hot-spots in Australia and Thailand.
Bacterial lung microbiota are correlated with lung inflammation and acute respiratory distress syndrome (ARDS) and altered in severe coronavirus disease (COVID-19). However, the association between lung microbiota (including fungi) and resolution of ARDS in COVID-19 remains unclear. We hypothesized that increased lung bacterial and fungal burdens are related to nonresolving ARDS and mortality in COVID-19.
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