Publications by authors named "Jason Hoang"
Article Synopsis
- Glucagon signaling is crucial for keeping blood sugar levels stable in mammals, and the ARRDC4 protein plays an important role in this process.
- Research shows that mice without the ARRDC4 protein struggle with glucagon responses and gluconeogenesis, leading to lower blood sugar after fasting.
- ARRDC4 also interacts with the glucagon receptor and its expression is influenced by insulin, highlighting its key role in regulating glucose metabolism and connecting insulin and glucagon pathways in the liver.
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits.
View Article and Find Full Text PDFBackground: The role of remdesivir in the treatment of patients in hospital with COVID-19 remains ill defined in a global context. The World Health Organization Solidarity randomized controlled trial (RCT) evaluated remdesivir in patients across many countries, with Canada enrolling patients using an expanded data collection format in the Canadian Treatments for COVID-19 (CATCO) trial. We report on the Canadian findings, with additional demographics, characteristics and clinical outcomes, to explore the potential for differential effects across different health care systems.
View Article and Find Full Text PDFPurpose: Advances in genomic techniques have led to increased use of next-generation sequencing (NGS). We evaluated the extent to which these tests guide treatment decisions.
Methods: We developed and distributed a survey assessing NGS use and outcomes to a survey pool of ASCO members.
Background: Prior to the introduction of rotavirus vaccines, rotavirus was the leading cause of severe gastroenteritis in infants and young children, and it continues to be the leading cause in countries without vaccination programs. Rotavirus gastroenteritis results in substantial economic burden and has a pronounced effect on the family of those who are ill. Both in Taiwan and in Vietnam, rotavirus illness is viewed as a priority disease.
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