Publications by authors named "Jason Hirshberg"
Article Synopsis
- - The study investigates the effects of stereotactic body radiation therapy (SBRT) on patients with localized prostate cancer who had high pretreatment International Prostate Symptom Scores (IPSS ≥ 15) at Georgetown University Hospital from 2009 to 2016.
- - 53 patients received SBRT, with a low incidence (7.5%) of Grade 3 urinary toxicity over a median follow-up of 3 years, and significant improvements were seen in urinary symptoms and quality of life shortly after treatment, maintained over 36 months.
- - The results indicate that SBRT is a well-tolerated option for men with high baseline IPSS, showing manageable side effects and lasting improvements in their urinary symptoms post-treatment
The adenoviruses are essential tools for basic research and therapeutic development. Robust methods for the generation of mutant and recombinant viruses are crucial for these diverse applications. Here we describe a simple plasmid-based method that permits highly efficient modification of the adenoviral genome and rapid production of high-titer virus stocks.
View Article and Find Full Text PDFReactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS have been implicated in the pathogenesis of autoimmune diseases. Here, ROS accumulation leads to apoptosis and autoantigen structural changes that result in novel specificities.
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