Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation.

Purpose: Currently, tumor-treating field (TTField) therapy utilizes a single "optimal" frequency of electric fields to achieve maximal cell death in a targeted population of cells. However, because of differences in cell size, shape, and ploidy during mitosis, optimal electric field characteristics for universal maximal cell death may not exist. This study investigated the anti-mitotic effects of modulating electric field frequency as opposed to utilizing uniform electric fields.

Efficacy and selectivity of tumor-treating field therapy for triple-negative breast cancer cells via in-house delivery device.

Purpose: Triple-negative breast cancer continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields are low-energy, low-frequency oscillating electric fields that induce an anti-proliferative effect on mitotic cells in glioblastoma multiforme, non-small cell lung cancer, and ovarian cancer. Little is known about effects of tumor-treating fields on triple-negative breast cancer and known research for tumor-treating fields only utilizes low (< 3 V/cm) electric field intensities.

The efficacy of written exposure therapy versus imaginal exposure delivered online for posttraumatic stress disorder: Design of a randomized controlled trial in Veterans.

Adapting evidence-based treatments for online delivery has potential to significantly increase the reach of effective care to Veterans with posttraumatic stress disorder (PTSD). This paper describes the rationale for and methods of a randomized controlled trial comparing the efficacy and efficiency of written exposure therapy versus imaginal exposure for PTSD delivered in a novel online and variable length format. Participants will be 300 Veterans seeking treatment for clinically significant symptoms of PTSD.

Effects of Different Athletic Playing Surfaces on Jump Height, Force, and Power.

Hatfield, DL, Murphy, KM, Nicoll, JX, Sullivan, WM, and Henderson, J. Effects of different athletic playing surfaces on jump height, force, and power. J Strength Cond Res 33(4): 965-973, 2019-Artificial turfs (ATs) have become more commonplace.

DiPyMe in SDS Micelles: Artifacts and Their Implications in the Interpretation of Micellar Properties.

This study provides experimental evidence that di(1-pyrenylmethyl) ether or DiPyMe, a well-known fluorescent probe employed to determine the microviscosity of surfactant or polymeric micelles, is being hydrolyzed in the presence of water upon UV irradiation. This effect was established from a careful analysis of the fluorescence spectra and decays acquired with aqueous solutions of DiPyMe dissolved in micelles of sodium dodecyl sulfate (SDS). The size of the SDS micelles could be adjusted from an aggregation number (N(agg)) of 70 to 172 by increasing the ionic strength of the aqueous solution from 0.

Synthesis of neutral nickel catalysts for ethylene polymerization--the influence of ligand size on catalyst stability.

A facile synthesis of nickel salicylaldimine complexes with labile dissociating ligands is described. In addition to producing highly active ethylene polymerization catalysts, important insights into the effect of ligand size on catalyst stability and information on the mechanism of polymerization are provided.