Publications by authors named "Jason H. Wu"

Background: Online grocery shopping is a growing source of food purchases in many countries. We investigated the effect of nudging consumers towards purchases of lower sodium products using a web browser extension.

Methods: This trial was conducted among individuals with hypertension who shopped for their groceries online in Australia.

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Background: Intake of trans-fatty acids (TFAs) is an established risk factor for cardiovascular disease. In April 2023, Nigeria passed regulations limiting TFA content in foods, fats, and oils, but the current level of TFA exposure in the Nigerian population is unknown.

Objectives: To quantify trans-fatty acid (TFA) biomarkers in dried blood spots from Nigerian adults in the Federal Capital Territory before policy enforcement, establish baseline levels for future evaluations, assess subgroup variations by demographic and socioeconomic factors, and compare TFA levels with data from 30 countries worldwide.

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Article Synopsis
  • The study investigates the relationship between different types of n-6 polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA), and mortality rates from various causes in a large UK Biobank cohort of over 257,000 individuals.
  • Findings indicate that higher levels of LA are linked to reduced total mortality risk, while higher levels of non-LA n-6 PUFAs are associated with increased mortality risk, particularly from non-cardiovascular and non-cancer causes.
  • The research emphasizes that LA and non-LA n-6 PUFAs should not be treated the same when evaluating health impacts, highlighting the importance of maintaining or increasing LA intake for better health outcomes.
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Background And Aims: Since the global burden of chronic kidney disease (CKD) is rising rapidly, the study aimed to assess the association of cardiovascular health (CVH) metrics with all-cause and cardiovascular disease (CVD) mortality among individuals with CKD.

Methods And Results: The cohort study included 5834 participants with CKD from the National Health and Nutrition Examination Survey 1999-2018. A composite CVH score was calculated based on smoking status, physical activity, body mass index, blood pressure, total cholesterol, diet quality, and glucose control.

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Article Synopsis
  • - Nigeria aims to limit industrial trans fatty acids (iTFA) in food to improve public health, specifically targeting ischaemic heart disease (IHD), but the impact and costs are unclear.
  • - Using Markov cohort models, researchers estimated that a mandatory iTFA limit would prevent nearly 10,000 IHD deaths and save around $90 million in healthcare costs over the first decade.
  • - The analysis suggests that implementing this policy is cost-effective and could lead to significant health benefits, supporting the idea of regulating iTFAs as a beneficial health strategy for Nigeria.
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The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP.

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Background: Nutrient profiling systems (NPSs) use algorithms to evaluate the nutritional quality of foods and beverages. Criterion validation, which assesses the relationship between consuming foods rated as healthier by the NPS and objective measures of health, is essential to ensure the accuracy of NPSs.

Objective: We examined and compared NPSs that have undergone criterion validity testing in relation to diet-related disease risk and risk markers.

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Objectives: To model the potential health gains and cost-effectiveness of a mandatory limit of industrial trans fatty acids (iTFA) in Kenyan foods.

Design: Multiple cohort proportional multistate life table model, incorporating existing data from the Global Burden of Disease study, pooled analyses of observational studies and peer-reviewed evidence of healthcare and policy implementation costs.

Setting: Kenya.

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Background: Postsecondary education institutions, where hundreds of millions of people work and study globally, are a key setting for retail food environment interventions.

Objective: We aimed to synthesize the evidence for the effectiveness of retail food environment interventions in improving the healthiness of dietary behavior of students and staff in postsecondary education settings.

Methods: Academic databases were searched for randomized controlled trials (RCTs) and quasi-experimental studies published until August 2023.

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Background: There is growing interest in Food is Medicine programs that incorporate food-based interventions into health care for patients with diet-related conditions.

Objectives: We aimed to test the feasibility of a "produce prescription" program and its impact on diet quality for people with type 2 diabetes (T2D) experiencing food insecurity in Australia.

Methods: We conducted a pre-post intervention study in n = 50 adults experiencing food insecurity with T2D and glycated hemoglobin (HbA1c) ≥8%.

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Article Synopsis
  • - The study evaluated how different omega-3 fatty acids, especially from seafood and plants, relate to the risk of developing chronic kidney disease (CKD) in a large pooled analysis of 19 studies from around the world, up to May 2020.
  • - Among 25,570 participants followed for an average of 11.3 years, 19.3% developed CKD, with higher seafood-derived omega-3 levels linked to a lower risk of CKD, while plant-derived omega-3s showed no significant association.
  • - The findings suggested that higher consumption of seafood omega-3s could lead to a 13% reduction in the risk of CKD, but plant-based sources like alpha-linolenic
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Objective: To examine the labelling status of -fat of pre-packaged foods sold in Hong Kong.

Design: Data from 19 027 items in the 2019 FoodSwitch Hong Kong database were used. Ingredient lists were screened to identify specific (e.

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We examined the prevalence and magnitude of price promotions among purchases of packaged foods and beverages in Australia, as well as the contribution of price-promoted foods and beverages to apparent energy intake. We utilized grocery purchase data from a nationally representative panel of 10 000 households in 2019 (NielsenIQ Homescan panel), combined with a food nutrition dataset (FoodSwitch). Nutritional quality was defined using the Australian and New Zealand Health Star Rating (HSR), where products with an HSR <3.

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Background: High dietary sodium intake is a leading cause of hypertension. A major source of dietary sodium is salt added to processed food products available in retail food environments. The fast-growing online grocery shopping setting provides new opportunities for salt reduction interventions that support consumers in choosing healthier options.

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Underconsumption of dietary fiber is prevalent worldwide and is associated with multiple adverse health conditions. Despite the importance of fiber, the labeling of fiber content on packaged foods and beverages is voluntary in most countries, making it challenging for consumers and policy makers to monitor fiber consumption. Here, we developed a machine learning approach for automated and systematic prediction of fiber content using nutrient information commonly available on packaged products.

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Unhealthy diets are underpinned by the over-consumption of packaged products. Data describing the ingredient composition of these products is limited. We sought to define the ingredients used in Australian packaged foods and beverages and assess associations between the number of ingredients and existing health indicators.

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Objective: To assess the contribution of different food groups to total salt purchases and to evaluate the estimated reduction in salt purchases if mandatory maximum salt limits in South African legislation were being complied with.

Design: This study conducted a cross-sectional analysis of purchasing data from Discovery Vitality members. Data were linked to the South African FoodSwitch database to determine the salt content of each food product purchased.

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Background: In rural China, mortality surveillance data may be an alternative to primary data collection in clinical trials; SmartVA (verbal autopsy) is also a potential alternative for endpoint adjudication. The feasibility and validity of both need to be assessed.

Methods: We used mortality data from the first 24 months of the China Salt Substitute and Stroke Study (SSaSS) trial and assessed the agreement between (1) mortality surveillance data and face-to-face visits for fact of death; (2) mortality surveillance data and SSaSS adjudication for causes of death; (3) SmartVA and SSaSS adjudication for causes of death; (4) cause-specific mortality fraction of different methods.

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Objective: To describe the Na concentration of pre-packaged foods available in Hong Kong.

Design: The Na concentrations (mg/100 g or mg/100 ml or per serving) of all pre-packaged foods available for sale in major supermarket chains in Hong Kong were obtained from the 2017 Hong Kong FoodSwitch database. Median and interquartile range (IQR) of Na concentration for different food groups and the proportion of foods and beverages considered low and high Na (<120 mg/100 g or mg/100 ml and >600 mg/100 g or mg/100 ml, respectively) were determined.

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Objective: To evaluate the associations between prediabetes and the risk of all cause mortality and incident cardiovascular disease in the general population and in patients with a history of atherosclerotic cardiovascular disease.

Design: Updated meta-analysis.

Data Sources: Electronic databases (PubMed, Embase, and Google Scholar) up to 25 April 2020.

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Private-label products, products owned by supermarkets, are a growing area of the food supply. The aim of this study was to assess the effect of an intervention that provided an Australian supermarket ('intervention supermarket') with comparative nutrition data to improve the healthiness of their private-label range. Between 2015 and 2016, the intervention supermarket received reports that ranked the nutritional quality of their products against competitors.

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The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in a random subsample of villages every 12 months over 3 years to track progress against key assumptions underlying study design.

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Objective: To examine prospective associations of clinically relevant depressive symptoms with cognitive functions and rates of cognitive decline among Chinese adults aged 45 years and older.

Methods: Data was from the China Health and Retirement Longitudinal Study (CHARLS) with a follow-up of 4 years. Based on the Chinese version of 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), clinically relevant depressive symptoms were defined with a CESD-10 score≥10 points.

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